PMID- 27061869
OWN - NLM
STAT- MEDLINE
DCOM- 20170210
LR  - 20181202
IS  - 1724-191X (Electronic)
IS  - 1120-1797 (Linking)
VI  - 32
IP  - 3
DP  - 2016 Mar
TI  - SBRT for prostate cancer: Challenges and features from a physicist prospective.
PG  - 479-84
LID - S1120-1797(16)30006-0 [pii]
LID - 10.1016/j.ejmp.2016.03.011 [doi]
AB  - Emerging data are showing the safety and the efficacy of Stereotactic Body 
      Radiation Therapy (SBRT) in prostate cancer management. In this context, the 
      medical physicists are regularly involved to review the appropriateness of the 
      adopted technology and to proactively study new solutions. From the physics point 
      of view there are two major challenges in prostate SBRT: (1) mitigation of 
      geometrical uncertainty and (2) generation of highly conformal dose distributions 
      that maximally spare the OARs. Geometrical uncertainties have to be limited as 
      much as possible in order to avoid the use of large PTV margins. Furthermore, 
      advanced planning and delivery techniques are needed to generate maximally 
      conformal dose distributions. In this non-systematic review the technology and 
      the physics aspects of SBRT for prostate cancer were analyzed. In details, the 
      aims were: (i) to describe the rationale of reducing the number of fractions 
      (i.e. increasing the dose per fraction), (ii) to analyze the features to be 
      accounted for performing an extreme hypo-fractionation scheme (>6-7Gy), and (iii) 
      to describe technological solutions for treating in a safe way. The analysis of 
      outcomes, toxicities, and other clinical aspects are not object of the present 
      evaluation.
CI  - Copyright (c) 2016 Associazione Italiana di Fisica Medica. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Mancosu, Pietro
AU  - Mancosu P
AD  - Humanitas Clinical and Research Hospital, Rozzano, Milano, Italy. Electronic 
      address: pietro.mancosu@humanitas.it.
FAU - Clemente, Stefania
AU  - Clemente S
AD  - Azienda Ospedaliera Universitaria Federico II Napoli, Italy.
FAU - Landoni, Valeria
AU  - Landoni V
AD  - Istituto Nazionale Tumori Regina Elena, Roma, Italy.
FAU - Ruggieri, Ruggero
AU  - Ruggieri R
AD  - Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
FAU - Alongi, Filippo
AU  - Alongi F
AD  - Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy.
FAU - Scorsetti, Marta
AU  - Scorsetti M
AD  - Humanitas Clinical and Research Hospital, Rozzano, Milano, Italy; Department of 
      Biomedical Sciences, Humanitas University, Rozzano, Milano, Italy.
FAU - Stasi, Michele
AU  - Stasi M
AD  - Azienda Ospedaliera Ordine Mauriziano di Torino, Torino, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20160406
PL  - Italy
TA  - Phys Med
JT  - Physica medica : PM : an international journal devoted to the applications of 
      physics to medicine and biology : official journal of the Italian Association of 
      Biomedical Physics (AIFB)
JID - 9302888
SB  - IM
MH  - Dose Fractionation, Radiation
MH  - Health Physics
MH  - Humans
MH  - Male
MH  - Prostatic Neoplasms/*radiotherapy
MH  - Radiosurgery/*methods
OTO - NOTNLM
OT  - Medical physics
OT  - Prostate
OT  - SABR
OT  - SBRT
EDAT- 2016/04/12 06:00
MHDA- 2017/02/12 06:00
CRDT- 2016/04/11 06:00
PHST- 2015/12/01 00:00 [received]
PHST- 2016/02/29 00:00 [revised]
PHST- 2016/03/12 00:00 [accepted]
PHST- 2016/04/11 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2017/02/12 06:00 [medline]
AID - S1120-1797(16)30006-0 [pii]
AID - 10.1016/j.ejmp.2016.03.011 [doi]
PST - ppublish
SO  - Phys Med. 2016 Mar;32(3):479-84. doi: 10.1016/j.ejmp.2016.03.011. Epub 2016 Apr 
      6.