PMID- 27062336
OWN - NLM
STAT- MEDLINE
DCOM- 20170501
LR  - 20170619
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 27
IP  - 5
DP  - 2016 Aug
TI  - Periostin as a biomarker for the diagnosis of pediatric asthma.
PG  - 521-6
LID - 10.1111/pai.12575 [doi]
AB  - BACKGROUND: There are some biomarkers for asthma diagnosis but they are often 
      difficult in clinical use, particularly in pediatric cases. Periostin is an 
      extracellular matrix protein, upregulated in response to IL-4 or IL-13. Serum 
      periostin is expected to be used as a non-invasive biomarker for asthma diagnosis 
      and management. METHODS: Twenty-eight children with asthma (BA) and 27 children 
      without asthma (patients with pectus excavatum, etc. as control group) aged 6-16 
      years were included. Bronchial asthma was diagnosed according to International 
      Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Fractional 
      exhaled nitric oxide (FeNO), lung function, blood eosinophil counts, total 
      immunoglobulin E (IgE) levels, and serum periostin levels were assessed. Results 
      were compared between BA and controls. Asthma diagnostic accuracies were 
      calculated using receiver operating characteristics (ROC) curve analyses. 
      RESULTS: Serum periostin levels in the BA group were significantly higher than 
      those in the control group [medians (with interquartile ranges), 134.0 
      (116.3-166.3) vs. 112.0 (97.0-132.0) ng/ml; p = 0.012]. The area under the ROC 
      curve (AUC) for periostin, FeNO, and eosinophil counts were 0.70, 0.72, and 0.84, 
      respectively. After the exclusion of controls with pectus excavatum, AUC for 
      periostin, forced expiratory volume in 1 s (FEV1 ), and maximum mid-expiratory 
      flow rate (MMF) were 0.75, 0.74, and 0.80, respectively. CONCLUSION: Serum 
      periostin levels were significantly higher in children with asthma. ROC AUC 
      values for periostin were equivalent to conventional biomarkers, including FeNO 
      levels and lung function testing, indicating the utility of serum periostin 
      levels in diagnosing asthma in children.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Inoue, Takashi
AU  - Inoue T
AD  - Department of Pediatrics, Jikei University Daisan Hospital, Tokyo, Japan.
AD  - Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan.
FAU - Akashi, Kenichi
AU  - Akashi K
AD  - Department of Pediatrics, Jikei University Daisan Hospital, Tokyo, Japan.
FAU - Watanabe, Masako
AU  - Watanabe M
AD  - Department of Pediatrics, Jikei University Daisan Hospital, Tokyo, Japan.
FAU - Ikeda, Yuichi
AU  - Ikeda Y
AD  - Central Clinical Laboratory, Jikei University Hospital, Tokyo, Japan.
FAU - Ashizuka, Shuichi
AU  - Ashizuka S
AD  - Department of Surgery, Division of Pediatric Surgery, Jikei University School of 
      Medicine, Tokyo, Japan.
FAU - Motoki, Takanori
AU  - Motoki T
AD  - Department of Pediatrics, Jikei University Daisan Hospital, Tokyo, Japan.
FAU - Suzuki, Ryohei
AU  - Suzuki R
AD  - Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
FAU - Sagara, Nagatoshi
AU  - Sagara N
AD  - Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
FAU - Yanagida, Noriyuki
AU  - Yanagida N
AD  - Department of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan.
FAU - Sato, Sakura
AU  - Sato S
AD  - Department of Allergy, Clinical Research Center for Allergy and Rheumatology, 
      Sagamihara National Hospital, Kanagawa, Japan.
FAU - Ebisawa, Motohiro
AU  - Ebisawa M
AD  - Department of Allergy, Clinical Research Center for Allergy and Rheumatology, 
      Sagamihara National Hospital, Kanagawa, Japan.
FAU - Ohta, Shoichiro
AU  - Ohta S
AD  - Department of Laboratory Medicine, Saga Medical School, Saga, Japan.
FAU - Ono, Jyunya
AU  - Ono J
AD  - Shino-Test Corporation, Kanagawa, Japan.
FAU - Izuhara, Kenji
AU  - Izuhara K
AD  - Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga 
      Medical School, Saga Japan.
FAU - Katsunuma, Toshio
AU  - Katsunuma T
AD  - Department of Pediatrics, Jikei University Daisan Hospital, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160518
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Interleukin-13)
RN  - 0 (POSTN protein, human)
RN  - 0 (Serpins)
RN  - 0 (squamous cell carcinoma-related antigen)
RN  - 207137-56-2 (Interleukin-4)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Pediatr Allergy Immunol. 2016 Aug;27(5):445
MH  - Adolescent
MH  - Antigens, Neoplasm/blood
MH  - Asthma/*diagnosis
MH  - Biomarkers/*blood/metabolism
MH  - Cell Adhesion Molecules/*blood
MH  - Child
MH  - Eosinophils/cytology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interleukin-13/blood
MH  - Interleukin-4/blood
MH  - Leukocyte Count
MH  - Male
MH  - Nitric Oxide/metabolism
MH  - Serpins/blood
MH  - Spirometry
OTO - NOTNLM
OT  - FeNO
OT  - ROC curve
OT  - asthma
OT  - biomarker
OT  - children
OT  - lung function
OT  - periostin
EDAT- 2016/04/12 06:00
MHDA- 2017/05/02 06:00
CRDT- 2016/04/11 06:00
PHST- 2016/04/05 00:00 [accepted]
PHST- 2016/04/11 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2017/05/02 06:00 [medline]
AID - 10.1111/pai.12575 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2016 Aug;27(5):521-6. doi: 10.1111/pai.12575. Epub 2016 
      May 18.