PMID- 27062364
OWN - NLM
STAT- MEDLINE
DCOM- 20161114
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 18
DP  - 2016 Apr 10
TI  - Analyzing myocardial torsion based on tissue phase mapping cardiovascular 
      magnetic resonance.
PG  - 15
LID - 10.1186/s12968-016-0234-5 [doi]
LID - 15
AB  - BACKGROUND: The purpose of this work is to analyze differences in left 
      ventricular torsion between volunteers and patients with non-ischemic 
      cardiomyopathy based on tissue phase mapping (TPM) cardiovascular magnetic 
      resonance (CMR). METHODS: TPM was performed on 27 patients with non-ischemic 
      cardiomyopathy and 14 normal volunteers. Patients underwent a standard CMR 
      including late gadolinium enhancement (LGE) for the assessment of myocardial scar 
      and ECG-gated cine CMR for global cardiac function. TPM was acquired in 
      short-axis orientation at base, mid, and apex for all subjects. After evaluation 
      by experienced observers, the patients were divided in subgroups according to the 
      presence or absence of LGE (LGE+/LGE-), local wall motion abnormalities 
      (WM+/WM-), and having a preserved (>/=50%) or reduced (<50%) ejection fraction 
      (EF+/EF-). TPM data was semi-automatically segmented and global LV torsion was 
      computed for each cardiac time frame for endocardial and epicardial layers, and 
      for the entire myocardium. RESULTS: Maximum myocardial torsion was significantly 
      lower for patients with reduced EF compared to controls (0.21 +/- 0.15 degrees /mm vs. 
      0.36 +/- 0.11 degrees /mm, p = 0.018), but also for patients with wall motion abnormalities 
      (0.21 +/- 0.13 degrees /mm vs. 0.36 +/- 0.11 degrees /mm, p = 0.004). Global myocardial torsion 
      showed a positive correlation (r = 0.54, p < 0.001) with EF. Moreover, 
      endocardial torsion was significantly higher than epicardial torsion for EF+ 
      subjects (0.56 +/- 0.33 degrees /mm vs. 0.34 +/- 0.18 degrees /mm, p = 0.039) and for volunteers 
      (0.46 +/- 0.16 degrees /mm vs. 0.30 +/- 0.09 degrees /mm, p = 0.004). The difference in maximum 
      torsion between endo- and epicardial layers was positively correlated with EF 
      (r = 0.47, p = 0.002) and age (r = 0.37, p = 0.016) for all subjects. 
      CONCLUSIONS: TPM can be used to detect significant differences in LV torsion in 
      patients with reduced EF and in the presence of local wall motion abnormalities. 
      We were able to quantify torsion differences between the endocardium and 
      epicardium, which vary between patient subgroups and are correlated to age and 
      EF.
FAU - Chitiboi, Teodora
AU  - Chitiboi T
AD  - Jacobs University Bremen, Bremen, Germany. teodora.chitiboi@mevis.fraunhofer.de.
AD  - Fraunhofer MEVIS, Bremen, Germany. teodora.chitiboi@mevis.fraunhofer.de.
FAU - Schnell, Susanne
AU  - Schnell S
AD  - Department of Radiology, Northwestern University, Chicago, IL, USA.
FAU - Collins, Jeremy
AU  - Collins J
AD  - Department of Radiology, Northwestern University, Chicago, IL, USA.
FAU - Carr, James
AU  - Carr J
AD  - Department of Radiology, Northwestern University, Chicago, IL, USA.
FAU - Chowdhary, Varun
AU  - Chowdhary V
AD  - Department of Radiology, Northwestern University, Chicago, IL, USA.
FAU - Honarmand, Amir Reza
AU  - Honarmand AR
AD  - Department of Radiology, Northwestern University, Chicago, IL, USA.
FAU - Hennemuth, Anja
AU  - Hennemuth A
AD  - Fraunhofer MEVIS, Bremen, Germany.
FAU - Linsen, Lars
AU  - Linsen L
AD  - Jacobs University Bremen, Bremen, Germany.
FAU - Hahn, Horst K
AU  - Hahn HK
AD  - Jacobs University Bremen, Bremen, Germany.
AD  - Fraunhofer MEVIS, Bremen, Germany.
FAU - Markl, Michael
AU  - Markl M
AD  - Department of Radiology, Northwestern University, Chicago, IL, USA.
LA  - eng
GR  - R01 HL117888/HL/NHLBI NIH HHS/United States
GR  - 1R01 HL117888/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160410
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomechanical Phenomena
MH  - Cardiomyopathies/*diagnosis/etiology/pathology/physiopathology
MH  - Contrast Media
MH  - Endocardium/pathology/physiopathology
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/pathology
MH  - Observer Variation
MH  - Pericardium/pathology/physiopathology
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - *Stroke Volume
MH  - Torsion, Mechanical
MH  - *Ventricular Function, Left
PMC - PMC4826723
OTO - NOTNLM
OT  - Cardiovascular magnetic resonanace
OT  - Myocardial velocities
OT  - Non-ischemic cardiomyopathy
OT  - Tissue phase mapping
OT  - Torsion
EDAT- 2016/04/12 06:00
MHDA- 2016/11/15 06:00
PMCR- 2016/04/10
CRDT- 2016/04/11 06:00
PHST- 2015/12/16 00:00 [received]
PHST- 2016/03/15 00:00 [accepted]
PHST- 2016/04/11 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2016/11/15 06:00 [medline]
PHST- 2016/04/10 00:00 [pmc-release]
AID - S1097-6647(23)00956-0 [pii]
AID - 234 [pii]
AID - 10.1186/s12968-016-0234-5 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2016 Apr 10;18:15. doi: 10.1186/s12968-016-0234-5.