PMID- 27062898
OWN - NLM
STAT- MEDLINE
DCOM- 20170925
LR  - 20221207
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 429
DP  - 2016 Jul 5
TI  - Association of polymorphisms in the MyD88, IRAK4 and TRAF6 genes and 
      susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a southern 
      Han Chinese population.
PG  - 114-9
LID - S0303-7207(16)30108-3 [pii]
LID - 10.1016/j.mce.2016.04.003 [doi]
AB  - Type 2 diabetes mellitus (T2DM) has been linked to a state of low-grade 
      inflammation resulting from abnormalities in the innate immune pathway. MyD88 is 
      an essential adaptor protein for TLR signaling, which is involved in activating 
      NF-kappaB through IRAK4 and TRAF6. To investigate the effects of the MyD88, IRAK4 and 
      TRAF6 polymorphisms in the susceptibility of T2DM and diabetic vascular 
      complications, eight SNPs were analyzed in 553 T2DM patients and 553 matched 
      healthy controls. Gene-gene interactions and haplotype associations were also 
      evaluated. We found a significant increased risk of T2DM for the AG genotype of 
      rs6853 in MyD88 gene and the CT genotype of rs4251532 in IRAK4 gene. Significant 
      association was also found between rs16928973 in TRAF6 gene and diabetic 
      nephropathy (DN) under the allelic model. Moreover, the TA haplotype in TRAF6 was 
      negatively associated with DN. No significant gene-gene interactions were found. 
      In conclusion, our results indicate that the polymorphisms in TLR-MyD88-NF-kappaB 
      signaling pathway confer genetic susceptibility to T2DM and DN.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Guo, Congcong
AU  - Guo C
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China.
FAU - Zhang, Liju
AU  - Zhang L
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China.
FAU - Nie, Lihong
AU  - Nie L
AD  - Department of Endocrine, The First Affiliated Hospital of Jinan University, 
      Guangzhou 510632, China.
FAU - Zhang, Na
AU  - Zhang N
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China.
FAU - Xiao, Di
AU  - Xiao D
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China.
FAU - Ye, Xingguang
AU  - Ye X
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China.
FAU - Ou, Meiling
AU  - Ou M
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China.
FAU - Zhang, Baohuan
AU  - Zhang B
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China.
FAU - Wang, Man
AU  - Wang M
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China.
FAU - Lin, Hansheng
AU  - Lin H
AD  - Department of Medical Statistics, School of Medicine, Jinan University, Guangzhou 
      510632, China.
FAU - Yang, Guang
AU  - Yang G
AD  - Department of Parasitology, School of Medicine, Jinan University, Guangzhou 
      510632, China; Key Laboratory of Environmental Exposure and Health in Guangzhou, 
      Jinan University, Guangzhou 510632, China. Electronic address: 
      guangyangphd@gmail.com.
FAU - Jing, Chunxia
AU  - Jing C
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      510632, China; Key Laboratory of Environmental Exposure and Health in Guangzhou, 
      Jinan University, Guangzhou 510632, China. Electronic address: jcxphd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160408
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (TNF Receptor-Associated Factor 6)
RN  - EC 2.7.11.1 (IRAK4 protein, human)
RN  - EC 2.7.11.1 (Interleukin-1 Receptor-Associated Kinases)
SB  - IM
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Demography
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Diabetic Angiopathies/genetics
MH  - Diabetic Nephropathies/*genetics
MH  - Epistasis, Genetic
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Humans
MH  - Interleukin-1 Receptor-Associated Kinases/*genetics
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Myeloid Differentiation Factor 88/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - TNF Receptor-Associated Factor 6/*genetics
OTO - NOTNLM
OT  - Genetics
OT  - IRAK4
OT  - MyD88
OT  - T2DM
OT  - TRAF6
EDAT- 2016/04/12 06:00
MHDA- 2017/09/26 06:00
CRDT- 2016/04/12 06:00
PHST- 2016/02/17 00:00 [received]
PHST- 2016/04/05 00:00 [revised]
PHST- 2016/04/06 00:00 [accepted]
PHST- 2016/04/12 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2017/09/26 06:00 [medline]
AID - S0303-7207(16)30108-3 [pii]
AID - 10.1016/j.mce.2016.04.003 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2016 Jul 5;429:114-9. doi: 10.1016/j.mce.2016.04.003. Epub 
      2016 Apr 8.