PMID- 27063085
OWN - NLM
STAT- MEDLINE
DCOM- 20170106
LR  - 20201019
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 90
DP  - 2016 May
TI  - Sarcoidosis in celiac disease: A page written by genetic variants in IL-18 miRNAs 
      target site?
PG  - 51-2
LID - S0306-9877(16)00088-8 [pii]
LID - 10.1016/j.mehy.2016.03.004 [doi]
AB  - Sarcoidosis is a chronic idiopathic granulomatous disease. Interleukin-18 (IL-18) 
      has been strongly implicated in the pathogenesis of sarcoidosis. Sarcoidosis 
      shows characteristic microRNAs (miRNAs) profiles. MiRNAs have recently emerged as 
      a new class of modulators of gene expression. MiRNAs are involved in 
      susceptibility to a number of autoimmune diseases promoting and inhibiting the 
      gene expression of different Th1 pro-inflammatory cytokines including IL18. 
      Sarcoidosis has been connected with a variety of autoimmune disorders including 
      celiac disease (CD). CD is a chronic, immune-mediated condition of the small 
      intestine caused by permanent intolerance to dietary gluten. IL-18 has been 
      reported to play an important role in inducing and maintaining inflammation after 
      gluten exposure. MiRNAs expression is significantly altered in CD patients. We 
      hypothesize that sarcoidosis and CD may be the result of common genetic variants 
      in IL-18 miRNA target site.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Mormile, Raffaella
AU  - Mormile R
AD  - Division of Pediatrics and Neonatology, Moscati Hospital, Aversa, Italy. 
      Electronic address: raffaellamormile@alice.it.
LA  - eng
PT  - Journal Article
DEP - 20160317
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (MicroRNAs)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (STAT1 protein, human)
RN  - 8002-80-0 (Glutens)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Binding Sites
MH  - Celiac Disease/*complications/diagnosis/genetics
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Glutens/adverse effects
MH  - Humans
MH  - Interferon-gamma/metabolism
MH  - Interleukin-18/*genetics
MH  - MicroRNAs/*genetics
MH  - STAT1 Transcription Factor/biosynthesis/genetics
MH  - Sarcoidosis/*etiology/genetics
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - Up-Regulation
EDAT- 2016/04/12 06:00
MHDA- 2017/01/07 06:00
CRDT- 2016/04/12 06:00
PHST- 2015/12/21 00:00 [received]
PHST- 2016/02/26 00:00 [revised]
PHST- 2016/03/05 00:00 [accepted]
PHST- 2016/04/12 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2017/01/07 06:00 [medline]
AID - S0306-9877(16)00088-8 [pii]
AID - 10.1016/j.mehy.2016.03.004 [doi]
PST - ppublish
SO  - Med Hypotheses. 2016 May;90:51-2. doi: 10.1016/j.mehy.2016.03.004. Epub 2016 Mar 
      17.