PMID- 27063247
OWN - NLM
STAT- MEDLINE
DCOM- 20170306
LR  - 20170801
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 161
DP  - 2016 Jul 1
TI  - The effects of caffeine ingestion on exercise-induced hypoalgesia: A pilot study.
PG  - 1-6
LID - S0031-9384(16)30140-8 [pii]
LID - 10.1016/j.physbeh.2016.04.005 [doi]
AB  - Exercise acutely reduces pain sensitivity, termed exercise-induced hypoalgesia 
      (EIH). The mechanisms underlying EIH remain unclear. Caffeine, a non-specific 
      adenosine receptor antagonist has been shown to attenuate EIH in 
      animals-suggesting the involvement of the adenosinergic system. This pilot study 
      investigated the effects of caffeine on pain sensitivity following cycling 
      exercise in college-aged men. Pressure pain threshold (PPT) and thermal pain 
      threshold (TPT) were assessed in thirteen low caffeine consuming men prior to 
      ingestion of a counter-balanced 5mg.kg(-1) dose of caffeine or a placebo (Pre), 
      60min following ingestion (Post-In), and then following a 15min bout of cycling 
      exercise (Post-Ex) at an intensity eliciting a quadriceps muscle pain rating of 3 
      out of 10. Nine of the men completed follow-up testing which was identical except 
      that the exercise consisted of 10min of cycling eliciting a pain rating of 5 out 
      of 10. Caffeine had no effect compared to placebo on PPT (p>/=0.15) or TPT (p>/=0.41) 
      60min following ingestion and following exercise. PPT increased from 599+/-176kPa 
      to 648+/-202kPa (p=0.009) and from 578+/-217kPa to 666+/-278kPa (p=0.01) following 15 
      and 10min of cycling, respectively. TPT increased from 46.2+/-2.9 degrees C to 46.8+/-2.6 degrees C 
      (p=0.008) following the 15min exercise bout, but did not change (46.4+/-3.6 degrees C vs. 
      46.8+/-3.3 degrees C; p=0.24) following the shorter, higher intensity exercise bout. The 
      results from this study indicate cycling exercise reduces pain sensitivity, 
      especially to pressure stimuli. Caffeine ingestion did not alter the EIH 
      response-suggesting adenosine may not play a prominent role in the EIH response 
      in humans.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Black, Christopher D
AU  - Black CD
AD  - University of Oklahoma, Department of Health and Exercise Science, Norman, OK 
      73019, USA. Electronic address: cblack@ou.edu.
FAU - Gonglach, Alexander R
AU  - Gonglach AR
AD  - University of Oklahoma, Department of Health and Exercise Science, Norman, OK 
      73019, USA.
FAU - Renfroe, Jessica B
AU  - Renfroe JB
AD  - University of Oklahoma, Department of Health and Exercise Science, Norman, OK 
      73019, USA.
FAU - Hight, Robert E
AU  - Hight RE
AD  - University of Oklahoma, Department of Health and Exercise Science, Norman, OK 
      73019, USA.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20160407
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Central Nervous System Stimulants)
RN  - 3G6A5W338E (Caffeine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Caffeine/*metabolism/therapeutic use
MH  - Central Nervous System Stimulants/*metabolism/therapeutic use
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - *Exercise
MH  - Hot Temperature/adverse effects
MH  - Humans
MH  - Hypesthesia/*drug therapy/*etiology
MH  - Male
MH  - Pain Threshold/physiology
MH  - Physical Stimulation/adverse effects
MH  - Pilot Projects
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Cycling
OT  - Pressure pain threshold
OT  - Thermal pain threshold
EDAT- 2016/04/12 06:00
MHDA- 2017/03/07 06:00
CRDT- 2016/04/12 06:00
PHST- 2016/02/09 00:00 [received]
PHST- 2016/03/14 00:00 [revised]
PHST- 2016/04/04 00:00 [accepted]
PHST- 2016/04/12 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2017/03/07 06:00 [medline]
AID - S0031-9384(16)30140-8 [pii]
AID - 10.1016/j.physbeh.2016.04.005 [doi]
PST - ppublish
SO  - Physiol Behav. 2016 Jul 1;161:1-6. doi: 10.1016/j.physbeh.2016.04.005. Epub 2016 
      Apr 7.