PMID- 27064875
OWN - NLM
STAT- MEDLINE
DCOM- 20170201
LR  - 20221207
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 62
IP  - 3
DP  - 2016 Mar 20
TI  - Monocyte chemoattractant protein-1 promoter -2518 polymorphism and susceptibility 
      to vasculitis, rheumatoid arthritis, and multiple sclerosis: A meta-analysis.
PG  - 65-71
AB  - The purpose of this study was to examine whether the monocyte chemoattractant 
      protein-1 (MCP-1) promoter -2518 A/G polymorphism (rs1024611) is associated with 
      susceptibility to vasculitis, rheumatoid arthritis (RA), or multiple sclerosis 
      (MS). A meta-analysis was conducted on the association between the MCP-1 -2518 
      A/G polymorphism and vasculitis, RA, and MS. Fourteen studies from 13 articles, 
      including six on vasculitis, five on RA, and three on MS, consisting of 3,038 
      patients and 3,545 controls were available for the meta-analysis. The 
      meta-analysis revealed no association between the MCP-1 -2518 G allele and 
      vasculitis (odds ratio [OR] = 0.990, 95% confidence interval [CI] = 0.749-1.309, 
      p = 0.943). Stratification by ethnicity indicated no association between the G 
      allele of the MCP-1 -2518 A/G polymorphism and vasculitis in Asians and 
      Caucasians. Meta-analysis by vasculitis type revealed an association between the 
      GG+GA genotype of the MCP-1 -2518 A/G polymorphism and Behcet's disease (BD; OR = 
      1.349, 95% CI = 1.013-1.796, p = 0.040). However, sensitivity analysis showed 
      that the association was not statistically significant after removing a study 
      that was conducted in China (OR = 1.030, 95% CI = 0.667-1.590, p = 0.895), which 
      indicated that the association was not statistically robust. The meta-analysis 
      revealed no association between the MCP-1 -2518 G allele and RA (OR = 0.986, 95% 
      CI = 0.890-1.093, p = 0.793) or MS (OR = 1.281, 95% CI = 0.802-2.046, p = 0.301). 
      Our meta-analysis demonstrates that the MCP-1 -2518 A/G polymorphism is not 
      associated with susceptibility to vasculitis, RA, or MS.
FAU - Lee, Y H
AU  - Lee YH
AD  - Korea University College of Medicine Division of Rheumatology, Department of 
      Internal Medicine Seoul Republic of Korea lyhcgh@korea.ac.kr.
FAU - Bae, S-C
AU  - Bae SC
AD  - Hanyang University Hospital for Rheumatic Diseases Department of Rheumatology 
      Seoul Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20160320
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics
MH  - Asian People/genetics
MH  - Chemokine CCL2/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Multiple Sclerosis/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Vasculitis/*genetics
MH  - White People/genetics
EDAT- 2016/04/12 06:00
MHDA- 2017/02/02 06:00
CRDT- 2016/04/12 06:00
PHST- 2015/12/29 00:00 [received]
PHST- 2016/03/15 00:00 [accepted]
PHST- 2016/04/12 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2017/02/02 06:00 [medline]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2016 Mar 20;62(3):65-71.