PMID- 2706516
OWN - NLM
STAT- MEDLINE
DCOM- 19890608
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 483
IP  - 2
DP  - 1989 Apr 3
TI  - Electrical stimulation of the medial prefrontal cortex supports both 'pure 
      reward' and 'reward-escape' behavior in rats.
PG  - 226-32
AB  - In female Sprague-Dawley rats, 8 of 12 medial prefrontal cortex (MPFC) sites that 
      yielded criterion self-stimulation behavior supported only self-stimulation, i.e. 
      were 'pure reward' in type. The remaining 4 sites supported behavior to escape 
      from experimenter-administered stimulation of the same parameters as well, i.e. 
      were 'reward-escape' in type. 'Pure reward' and 'reward-escape' sites in the MPFC 
      were distinguished by both the magnitude and temporal form of the escape response 
      functions generated, and by the prevalence of 'pounce-back', a vigorous and 
      repetitive barpressing during the 3-s MPFC stimulation-escape interval produced 
      by an effective barpress. The finding that both 'pure reward' and 'reward-escape' 
      patterns of behavior can be elicited by stimulation of the MPFC provides a basis 
      for further assessment of similarities and differences in medial prefrontal 
      cortical and lateral hypothalamic (LH) 'reward' systems. It is suggested that 
      'reward-escape' in the MPFC may be mediated by the activity of 'reward' neurons 
      which respond to stimulus offset, rather than by a secondary aversive process as 
      is proposed to underlie 'reward-escape' in the LH.
FAU - Miserendino, M J
AU  - Miserendino MJ
AD  - Department of Psychology, New York University, NY 10003.
FAU - Coons, E E
AU  - Coons EE
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Animals
MH  - Electric Stimulation
MH  - Escape Reaction/*physiology
MH  - Evoked Potentials
MH  - Female
MH  - Frontal Lobe/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Reward
EDAT- 1989/04/03 00:00
MHDA- 1989/04/03 00:01
CRDT- 1989/04/03 00:00
PHST- 1989/04/03 00:00 [pubmed]
PHST- 1989/04/03 00:01 [medline]
PHST- 1989/04/03 00:00 [entrez]
AID - 0006-8993(89)90167-4 [pii]
AID - 10.1016/0006-8993(89)90167-4 [doi]
PST - ppublish
SO  - Brain Res. 1989 Apr 3;483(2):226-32. doi: 10.1016/0006-8993(89)90167-4.