PMID- 2706517
OWN - NLM
STAT- MEDLINE
DCOM- 19890608
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 483
IP  - 2
DP  - 1989 Apr 3
TI  - Hedonic interactions of medial prefrontal cortex and nucleus reticularis 
      gigantocellularis.
PG  - 233-50
AB  - It has been shown that 'pure reward' and 'reward-escape' sites in the lateral 
      hypothalamus (LH) of rats respectively ameliorate and exacerbate nucleus 
      reticularis gigantocellularis (NGC) stimulation-induced aversion52. Conversely, 
      the present studies found that 'rewarding' medial prefrontal cortex (MPFC) 
      stimulation increased escape from NGC stimulation regardless of whether the MPFC 
      site tested was 'pure reward' or 'reward-escape' in type. This suggested that a 
      simple algebraic summation model of positive and negative affective processes may 
      not adequately describe the NGC-MPFC interaction. In a subsequent study, rats 
      were observed both to barpress less to obtain, and more to escape from, 
      'rewarding' MPFC stimulation during continuous NGC stimulation, supporting the 
      hypothesis that the observed MPFC stimulation-mediated increase in NGC 
      stimulation escape reflected an exacerbation of aversion. Finally, NGC 
      stimulation was seen to increase barpressing to obtain 'subreward' MPFC current 
      trains, indicating a potentiation of the reward value of such current. Results of 
      this series of studies suggests a hedonic interaction model of NGC and MPFC 
      characterized by reciprocal neuromodulation. The model is conceptualized as a 
      'neural opponent process' subserving affective 'balance' and 'feature 
      enhancement', and its possible relevance to the putative role of the MPFC in 
      cocaine use is discussed.
FAU - Miserendino, M J
AU  - Miserendino MJ
AD  - Department of Psychology, New York University, NY 10003.
FAU - Coons, E E
AU  - Coons EE
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Electric Stimulation
MH  - Escape Reaction/*physiology
MH  - Evoked Potentials
MH  - Female
MH  - Frontal Lobe/*physiology
MH  - Habituation, Psychophysiologic
MH  - Medulla Oblongata/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Reward
EDAT- 1989/04/03 00:00
MHDA- 1989/04/03 00:01
CRDT- 1989/04/03 00:00
PHST- 1989/04/03 00:00 [pubmed]
PHST- 1989/04/03 00:01 [medline]
PHST- 1989/04/03 00:00 [entrez]
AID - 0006-8993(89)90168-6 [pii]
AID - 10.1016/0006-8993(89)90168-6 [doi]
PST - ppublish
SO  - Brain Res. 1989 Apr 3;483(2):233-50. doi: 10.1016/0006-8993(89)90168-6.