PMID- 27065203
OWN - NLM
STAT- MEDLINE
DCOM- 20170404
LR  - 20220408
IS  - 1879-2472 (Electronic)
IS  - 0049-3848 (Linking)
VI  - 141
DP  - 2016 May
TI  - Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein 
      thrombosis complicating liver cirrhosis.
PG  - 189-95
LID - S0049-3848(16)30084-6 [pii]
LID - 10.1016/j.thromres.2016.03.024 [doi]
AB  - BACKGROUND: Portal vein thrombosis (PVT) is serious complication of liver 
      cirrhosis (LC), especially in the presence of hepatocellular carcinoma (HCC). The 
      liver plays a key role in homocysteine (Hcy) metabolism: mild 
      hyperhomocysteinemia (HHcy) has been described in LC. HHcy is a risk factor for 
      deep vein thrombosis. Methylen-tetrahydrofolate-reductase (MTHFR) C677T 
      polymorphism is the commonest determinant of mild HHcy and has been involved also 
      in cancer development. AIM: To investigate a possible relation between HHcy, 
      MTHFR status, HCC and PVT in patients affected by LC. MATERIALS AND METHODS: 100 
      patients affected by LC, 38 with (PVT group, 24 with HCC) and 62 without PVT (LC 
      group, 14 with HCC) sex-, age-, liver disease stage and etiology-matched were 
      assessed for thrombophilia, smoking status, plasma Hcy, MTHFRC677T polymorphism 
      and homocysteine-related vitamin status. RESULTS: A higher prevalence of HCC, 
      HHcy and MTHFR TT status was observed in PVT group. No significant difference in 
      vitamin status was observed between groups. Patients with HCC showed 
      significantly higher plasma Hcy and higher prevalence of HHcy than patients 
      without HCC. They had also higher prevalence of MTHFR TT status. In patients with 
      TT status (n=11) and HCC, 10 had HHcy e 9 had PVT. CONCLUSIONS: Mild HHcy is 
      associated to LC may have a role in PVT development and assessment of plasma Hcy 
      may be suggested in patients with LC (especially if complicated by HCC). 
      Association between HCC and MTHFR TT status is intriguing, due the postulated 
      role for this polymorphism in cancer: it may represent a possible link between 
      HCC and PVT.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Ventura, Paolo
AU  - Ventura P
AD  - Unit of Internal Medicine 2, Department of Medical and Surgical Science for 
      Children and Adults, University of Modena and Reggio Emilia, Italy. Electronic 
      address: paoloven@unimore.it.
FAU - Venturelli, Giorgia
AU  - Venturelli G
AD  - Unit of Internal Medicine 2, Department of Medical and Surgical Science for 
      Children and Adults, University of Modena and Reggio Emilia, Italy.
FAU - Marcacci, Matteo
AU  - Marcacci M
AD  - Unit of Internal Medicine 2, Department of Medical and Surgical Science for 
      Children and Adults, University of Modena and Reggio Emilia, Italy.
FAU - Fiorini, Massimo
AU  - Fiorini M
AD  - Unit of Internal Medicine 2, Department of Medical and Surgical Science for 
      Children and Adults, University of Modena and Reggio Emilia, Italy.
FAU - Marchini, Stefano
AU  - Marchini S
AD  - Unit of Internal Medicine 2, Department of Medical and Surgical Science for 
      Children and Adults, University of Modena and Reggio Emilia, Italy.
FAU - Cuoghi, Chiara
AU  - Cuoghi C
AD  - Unit of Internal Medicine 2, Department of Medical and Surgical Science for 
      Children and Adults, University of Modena and Reggio Emilia, Italy.
FAU - Pietrangelo, Antonello
AU  - Pietrangelo A
AD  - Unit of Internal Medicine 2, Department of Medical and Surgical Science for 
      Children and Adults, University of Modena and Reggio Emilia, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160325
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Aged
MH  - Carcinoma, Hepatocellular/blood/complications/genetics
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*complications/*genetics
MH  - Liver Cirrhosis/blood/*complications/genetics
MH  - Liver Neoplasms/blood/complications/genetics
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Portal Vein/pathology
MH  - Retrospective Studies
MH  - Venous Thrombosis/blood/*complications/genetics
OTO - NOTNLM
OT  - Hepatocellular carcinoma
OT  - Homocysteine
OT  - MTHFR status
OT  - Portal vein thrombosis
OT  - Thrombophilia
EDAT- 2016/04/12 06:00
MHDA- 2017/04/05 06:00
CRDT- 2016/04/12 06:00
PHST- 2015/08/22 00:00 [received]
PHST- 2016/01/04 00:00 [revised]
PHST- 2016/03/20 00:00 [accepted]
PHST- 2016/04/12 06:00 [entrez]
PHST- 2016/04/12 06:00 [pubmed]
PHST- 2017/04/05 06:00 [medline]
AID - S0049-3848(16)30084-6 [pii]
AID - 10.1016/j.thromres.2016.03.024 [doi]
PST - ppublish
SO  - Thromb Res. 2016 May;141:189-95. doi: 10.1016/j.thromres.2016.03.024. Epub 2016 
      Mar 25.