PMID- 27068496
OWN - NLM
STAT- MEDLINE
DCOM- 20180118
LR  - 20180307
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 35
IP  - 6
DP  - 2016 Dec
TI  - Central venous catheter related bloodstream infections in adult patients on home 
      parenteral nutrition: Prevalence, predictive factors, therapeutic outcome.
PG  - 1394-1398
LID - S0261-5614(16)00100-X [pii]
LID - 10.1016/j.clnu.2016.03.009 [doi]
AB  - BACKGROUND: The prevalence of central venous catheter (CVC)-related blood-stream 
      infections (CRBSI), infecting agents and the effectiveness of antibiotic therapy 
      were evaluated in 172 adult patients on Home Parenteral Nutrition (HPN) at the 
      Clinical Nutrition Outpatient Unit of Federico II University Hospital in Naples, 
      Italy. MATERIALS AND METHODS: The study population consisted of 127 oncological 
      (74%) and 45 (26%) non-oncological patients, for a total of 53,818 (median 104; 
      range 14-1080) CVC days. RESULTS: Ninety-four CRBSIs were diagnosed on 238 CVC 
      (infection rate 1.74/1000 CVC days). Coagulase negative (CoNs) Staphylococci were 
      the most frequently infecting agents (52.8% as single agent) with 17.1% 
      Staphylococcus epidermidis infections. Eighty-three percent S. epidermidis were 
      beta-lattamase producer (BLACT), 66.6% methicillin-resistant (MR) and 55.5% had a 
      MIC for Vancomicin >/=1. Gram-negative bacteria represented 18.6% infections, fungi 
      7.1%, finally 15% infections were polymicrobial. Previous catheterizations and 
      the presence of an enterocutaneous stoma were significantly related with a higher 
      infection risk (p < 0.0001 in both cases). CONCLUSIONS: CRBSI and antibiotic 
      resistance of infecting agents remain an important challenge in adult patients on 
      HPN; an active research on strategies to counteract the phenomena is required.
CI  - Copyright (c) 2016 Elsevier Ltd and European Society for Clinical Nutrition and 
      Metabolism. All rights reserved.
FAU - Santarpia, Lidia
AU  - Santarpia L
AD  - Internal Medicine and Clinical Nutrition, Department of Clinical Medicine and 
      Surgery, Federico II University, Naples, Italy. Electronic address: 
      lidia.santarpia@unina.it.
FAU - Buonomo, Antonio
AU  - Buonomo A
AD  - Infectious Disease Unit, Department of Clinical Medicine and Surgery, Federico II 
      University, Naples, Italy.
FAU - Pagano, Maria Carmen
AU  - Pagano MC
AD  - Internal Medicine and Clinical Nutrition, Department of Clinical Medicine and 
      Surgery, Federico II University, Naples, Italy.
FAU - Alfonsi, Lucia
AU  - Alfonsi L
AD  - Internal Medicine and Clinical Nutrition, Department of Clinical Medicine and 
      Surgery, Federico II University, Naples, Italy.
FAU - Foggia, Maria
AU  - Foggia M
AD  - Infectious Disease Unit, Department of Clinical Medicine and Surgery, Federico II 
      University, Naples, Italy.
FAU - Mottola, Michele
AU  - Mottola M
AD  - Department of Cardiac Surgery, Federico II University, Naples, Italy.
FAU - Marinosci, Geremia Zito
AU  - Marinosci GZ
AD  - Intensive Care Unit, Department of Neurosciences, Reproductive and 
      Odontostomatologic Sciences, Federico II University, Naples, Italy.
FAU - Contaldo, Franco
AU  - Contaldo F
AD  - Internal Medicine and Clinical Nutrition, Department of Clinical Medicine and 
      Surgery, Federico II University, Naples, Italy.
FAU - Pasanisi, Fabrizio
AU  - Pasanisi F
AD  - Internal Medicine and Clinical Nutrition, Department of Clinical Medicine and 
      Surgery, Federico II University, Naples, Italy.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160330
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents
MH  - Bacteremia/*epidemiology/etiology
MH  - Catheter-Related Infections/blood/*epidemiology/etiology/microbiology
MH  - Central Venous Catheters/adverse effects/*microbiology
MH  - Communicable Diseases/blood/*epidemiology/microbiology
MH  - Female
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Parenteral Nutrition, Home/*adverse effects
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Antibiotic resistance
OT  - Catheter related blood-stream infections
OT  - Central venous catheters
OT  - Home parenteral nutrition
EDAT- 2016/04/14 06:00
MHDA- 2018/01/19 06:00
CRDT- 2016/04/13 06:00
PHST- 2016/01/11 00:00 [received]
PHST- 2016/03/10 00:00 [revised]
PHST- 2016/03/14 00:00 [accepted]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2018/01/19 06:00 [medline]
PHST- 2016/04/13 06:00 [entrez]
AID - S0261-5614(16)00100-X [pii]
AID - 10.1016/j.clnu.2016.03.009 [doi]
PST - ppublish
SO  - Clin Nutr. 2016 Dec;35(6):1394-1398. doi: 10.1016/j.clnu.2016.03.009. Epub 2016 
      Mar 30.