PMID- 27069322
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160412
LR  - 20201001
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 31
IP  - 2
DP  - 2016 Apr
TI  - Hyperhomocysteinemia, MMPs and Cochlear Function: A Short Review.
PG  - 148-51
LID - 10.1007/s12291-015-0505-1 [doi]
AB  - Hyperhomocysteinemia (HHCY) has been demonstrated to affect cochlear 
      microvasculature as well as cochlear epithelial cells directly, with a resultant 
      alteration of the expression of matrix metalloproteinases (MMPs) and their 
      inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Hence, ascertaining 
      the optimum concentration of MMPs and TIMPs in the cochlea could help to inhibit 
      hearing loss due to HHCY by the administration of appropriate MMP inhibitors, 
      Since infections/inflammations as well as ototoxic antibiotics have a similar 
      mechanism of otic pathology, the cochlear damage they cause could also be 
      similarly prevented.
FAU - Bhargava, Seema
AU  - Bhargava S
AD  - Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, India.
FAU - Bhargava, Meghaa Shanta
AU  - Bhargava MS
AD  - Lady Hardinge Medical College, New Delhi, India.
FAU - Bhargava, Eishaan Kamta
AU  - Bhargava EK
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Maulana Azad Medical 
      College and Associated LNJPN, GNEC and GB Pant Hospitals, New Delhi, India.
FAU - Srivastava, L M
AU  - Srivastava LM
AD  - Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150428
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC4820424
OTO - NOTNLM
OT  - Cochlea
OT  - Hearing loss
OT  - Hyperhomocysteinemia
OT  - MMPs
OT  - TIMPs
EDAT- 2016/04/14 06:00
MHDA- 2016/04/14 06:01
PMCR- 2017/04/01
CRDT- 2016/04/13 06:00
PHST- 2015/02/24 00:00 [received]
PHST- 2015/04/12 00:00 [accepted]
PHST- 2016/04/13 06:00 [entrez]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2016/04/14 06:01 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - 505 [pii]
AID - 10.1007/s12291-015-0505-1 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2016 Apr;31(2):148-51. doi: 10.1007/s12291-015-0505-1. 
      Epub 2015 Apr 28.