PMID- 27069328
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160412
LR  - 20201001
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 31
IP  - 2
DP  - 2016 Apr
TI  - Immuno-Modulatory Effect and Therapeutic Potential of Brugia malayi Cystatin in 
      Experimentally Induced Arthritis.
PG  - 203-8
LID - 10.1007/s12291-015-0515-z [doi]
AB  - Helminths are known to modulate host's immune system and understanding this 
      modulation can help in identification of novel therapeutic agents for autoimmune 
      diseases. In this study, we have assessed the immune-modulatory activity and the 
      therapeutic effect of Brugia malayi recombinant cystatin (rBmCys) in methylated 
      BSA (mBSA) induced arthritis using rodent model. Administration of rBmCys has 
      suppressed the severity of mBSA-arthritis in mastomys by reducing paw swelling 
      and other clinical disease parameters as evident from significantly decreased 
      arthritic index. The anti-arthritic effect of rBmCys was also confirmed by 
      decreased histopathological score for synovitis, bone erosion and fibrosis in the 
      tissue sections of paws. Further, this therapeutic effect of cystatin was found 
      to be associated with significantly decreased production of IFN-gamma and TNF-alpha and 
      increased release of IL-4 and IL-10 cytokines. These results implied that rBmCys 
      treatment has alleviated mBSA-induced arthritis and thus can be a promising 
      alternative agent for the treatment of arthritis.
FAU - Yadav, Ravi Shankar Prasad
AU  - Yadav RS
AD  - Department of Biochemistry & JB Tropical Disease Research Center, Mahatma Gandhi 
      Institute of Medical Sciences, Sevagram, Maharashtra 442 102 India.
FAU - Khatri, Vishal
AU  - Khatri V
AD  - Department of Biochemistry & JB Tropical Disease Research Center, Mahatma Gandhi 
      Institute of Medical Sciences, Sevagram, Maharashtra 442 102 India.
FAU - Amdare, Nitin
AU  - Amdare N
AD  - Department of Biochemistry & JB Tropical Disease Research Center, Mahatma Gandhi 
      Institute of Medical Sciences, Sevagram, Maharashtra 442 102 India.
FAU - Goswami, Kalyan
AU  - Goswami K
AD  - Department of Biochemistry & JB Tropical Disease Research Center, Mahatma Gandhi 
      Institute of Medical Sciences, Sevagram, Maharashtra 442 102 India.
FAU - Shivkumar, V B
AU  - Shivkumar VB
AD  - Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, 
      Maharashtra 442 102 India.
FAU - Gangane, Nitin
AU  - Gangane N
AD  - Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, 
      Maharashtra 442 102 India.
FAU - Reddy, Maryada Venkata Rami
AU  - Reddy MV
AD  - Department of Biochemistry & JB Tropical Disease Research Center, Mahatma Gandhi 
      Institute of Medical Sciences, Sevagram, Maharashtra 442 102 India.
LA  - eng
PT  - Journal Article
DEP - 20150723
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC4820427
OTO - NOTNLM
OT  - Brugia malayi cystatin
OT  - Methylated BSA
OT  - Rheumatoid arthritis
OT  - Therapeutic effect
EDAT- 2016/04/14 06:00
MHDA- 2016/04/14 06:01
PMCR- 2017/04/01
CRDT- 2016/04/13 06:00
PHST- 2015/05/21 00:00 [received]
PHST- 2015/07/15 00:00 [accepted]
PHST- 2016/04/13 06:00 [entrez]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2016/04/14 06:01 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - 515 [pii]
AID - 10.1007/s12291-015-0515-z [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2016 Apr;31(2):203-8. doi: 10.1007/s12291-015-0515-z. Epub 
      2015 Jul 23.