PMID- 27069498
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160412
LR  - 20220318
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 13
DP  - 2016
TI  - Hydroxycinnamic acid derivatives: a potential class of natural compounds for the 
      management of lipid metabolism and obesity.
PG  - 27
LID - 10.1186/s12986-016-0080-3 [doi]
LID - 27
AB  - Hydroxycinnamic acid derivatives are important class of polyphenolic compounds 
      originated from the Mavolanate-Shikimate biosynthesis pathways in plants. Several 
      simple phenolic compounds such as cinnamic acid, p-coumaric acid, ferulic acid, 
      caffeic acid, chlorgenic acid, and rosmarinic acid belong to this class. These 
      phenolic compounds possess potent antioxidant and anti-inflammatory properties. 
      These compounds were also showed potential therapeutic benefit in experimental 
      diabetes and hyperlipidemia. Recent evidences also suggest that they may serve as 
      valuable molecule for the treatment of obesity related health complications. In 
      adipose tissues, hydroxycinnamic acid derivatives inhibit macrophage infiltration 
      and nuclear factor kappaB (NF-kappaB) activation in obese animals. Hydroxycinnamic acid 
      derivatives also reduce the expression of the potent proinflammatory adipokines 
      tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and 
      plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion 
      of an anti-inflammatory agent adiponectin from adipocytes. Furthermore, 
      hydroxycinnamic acid derivatives also prevent adipocyte differentiation and lower 
      lipid profile in experimental animals. Through these diverse mechanisms 
      hydroxycinnamic acid derivatives reduce obesity and curtail associated adverse 
      health complications.
FAU - Alam, Md Ashraful
AU  - Alam MA
AD  - Department of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, 
      Bangladesh.
FAU - Subhan, Nusrat
AU  - Subhan N
AD  - School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South 
      Wales Australia.
FAU - Hossain, Hemayet
AU  - Hossain H
AD  - BCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research 
      (BCSIR), Dhaka, Bangladesh.
FAU - Hossain, Murad
AU  - Hossain M
AD  - Department of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, 
      Bangladesh.
FAU - Reza, Hasan Mahmud
AU  - Reza HM
AD  - Department of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, 
      Bangladesh.
FAU - Rahman, Md Mahbubur
AU  - Rahman MM
AD  - Department of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, 
      Bangladesh.
FAU - Ullah, M Obayed
AU  - Ullah MO
AUID- ORCID: 0000-0002-1175-3636
AD  - Department of Pharmaceutical Sciences, North South University Bangladesh, Dhaka, 
      Bangladesh.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160411
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC4827240
OTO - NOTNLM
OT  - Diabetes
OT  - Dyslipidemia
OT  - Hydroxycinnamic acid
OT  - Inflammation
OT  - Obesity
EDAT- 2016/04/14 06:00
MHDA- 2016/04/14 06:01
PMCR- 2016/04/11
CRDT- 2016/04/13 06:00
PHST- 2015/09/20 00:00 [received]
PHST- 2016/03/02 00:00 [accepted]
PHST- 2016/04/13 06:00 [entrez]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2016/04/14 06:01 [medline]
PHST- 2016/04/11 00:00 [pmc-release]
AID - 80 [pii]
AID - 10.1186/s12986-016-0080-3 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2016 Apr 11;13:27. doi: 10.1186/s12986-016-0080-3. eCollection 
      2016.