PMID- 27069510
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160412
LR  - 20201001
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 8
DP  - 2016
TI  - The usefulness of quantifying intraepidermal nerve fibers density in the 
      diagnostic of diabetic peripheral neuropathy: a cross-sectional study.
PG  - 31
LID - 10.1186/s13098-016-0146-4 [doi]
LID - 31
AB  - BACKGROUND: Distal symmetric polyneuropathy (DSPN) is the most common 
      complication of type 2 diabetes mellitus (T2DM) and the most common form of 
      peripheral neuropathy. DSPN increases the risk of foot ulceration up to 
      seven-fold, and is a significant risk factor in more than 60 % of the amputations 
      of the lower limbs in patients with T2DM. The aims of our study were to evaluate 
      the difference in the density of intraepidermal nerve fibers (IENF) in patients 
      with respectively without DSPN, to evaluate the strength of the relationship 
      between the symptomatology of the DSPN and IENF density and to define a cutoff 
      value of the IENF density for the diagnosis of DSPN. METHODS: We enrolled, 
      according to a consecutive, population-based method, 36 patients with T2DM 
      admitted in our Clinic. For all patients, we measured HbA1c, lipid profile, body 
      mass index and we assessed the presence and severity of DSPN using the evaluation 
      of clinical symptoms, nerve conduction velocity and IENF density quantification. 
      RESULTS: The presence of neuropathy was significantly associated with a decreased 
      density of IENF for both the proximal (11.6 vs. 14.9 fibers/mm; p = 0.014) and 
      the distal biopsies (7.2 vs. 8.6 fibers/mm; p = 0.020). The optimal threshold 
      value of IENF density (the point with the maximum sum of specificity and 
      sensitivity), according to our model, was 10.1 fibers/mm. CONCLUSIONS: Skin 
      biopsy followed by IENF density quantification is a valid, reliable tool for the 
      diagnosis of DSPN.
FAU - Timar, Bogdan
AU  - Timar B
AD  - Department III - Functional Sciences, "Victor Babes" University of Medicine and 
      Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
FAU - Popescu, Simona
AU  - Popescu S
AD  - Department VII - Internal Medicine, "Victor Babes" University of Medicine and 
      Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
FAU - Timar, Romulus
AU  - Timar R
AD  - Department VII - Internal Medicine, "Victor Babes" University of Medicine and 
      Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
FAU - Baderca, Flavia
AU  - Baderca F
AD  - Department II - Microscopic Morphology, "Victor Babes" University of Medicine and 
      Pharmacy, Timisoara, Romania.
FAU - Duica, Bogdan
AU  - Duica B
AD  - Department X - Surgery, "Victor Babes" University of Medicine and Pharmacy, 
      Timisoara, Romania.
FAU - Vlad, Mihaela
AU  - Vlad M
AD  - Department VII - Internal Medicine, "Victor Babes" University of Medicine and 
      Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
FAU - Levai, Codrina
AU  - Levai C
AD  - Legal Department, "Victor Babes" University of Medicine and Pharmacy, Timisoara, 
      Romania.
FAU - Balinisteanu, Bogdan
AU  - Balinisteanu B
AD  - Department II - Microscopic Morphology, "Victor Babes" University of Medicine and 
      Pharmacy, Timisoara, Romania.
FAU - Simu, Mihaela
AU  - Simu M
AD  - Department VIII - Neurosciences, "Victor Babes" University of Medicine and 
      Pharmacy, Timisoara, Romania.
LA  - eng
PT  - Journal Article
DEP - 20160411
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC4827180
OTO - NOTNLM
OT  - Diabetic peripheral neuropathy
OT  - Intraepidermal nerve fibers density
OT  - Skin biopsy
EDAT- 2016/04/14 06:00
MHDA- 2016/04/14 06:01
PMCR- 2016/04/11
CRDT- 2016/04/13 06:00
PHST- 2016/01/31 00:00 [received]
PHST- 2016/03/31 00:00 [accepted]
PHST- 2016/04/13 06:00 [entrez]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2016/04/14 06:01 [medline]
PHST- 2016/04/11 00:00 [pmc-release]
AID - 146 [pii]
AID - 10.1186/s13098-016-0146-4 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2016 Apr 11;8:31. doi: 10.1186/s13098-016-0146-4. 
      eCollection 2016.