PMID- 27070202
OWN - NLM
STAT- MEDLINE
DCOM- 20170623
LR  - 20170623
IS  - 1827-1618 (Electronic)
IS  - 0026-4725 (Linking)
VI  - 64
IP  - 4
DP  - 2016 Aug
TI  - Bioresorbable vascular scaffolds in STEMI patients: multimodality imaging 
      comparison in mid-term perspective.
PG  - 411-8
AB  - BACKGROUND: Bioresorbable vascular scaffolds (BVS) represent an exciting and 
      novel coronary intervention technology. BVS implantation could play an important 
      role in the acute ST elevation myocardial infarction (STEMI) setting, with mid- 
      and long-term follow-up data still scarce. METHODS: PRAGUE-19 is a prospective 
      double-center single arm study that tests the performance and safety of BVS 
      implantation during primary percutaneous coronary intervention (pPCI) in the 
      STEMI setting. During the enrollment period 70 patients were included, 
      quantitative coronary angiography (QCA) was done immediately after BVS 
      implantation and optical coherence tomography (OCT) study was suggested but not 
      mandatory; subsequently serial clinical follow-up was scheduled and research 
      computed tomography (CT) angiography at 1 year was performed. The current study 
      focused on a group of 22 patients who had complete multi-imaging data (QCA and 
      OCT immediately post-procedure and CT at 1 year after implantation) and aimed to 
      analyze the quantitative measurements of these different techniques. RESULTS: All 
      25 BVS implanted in 22 patients were widely patent at 1-year CT angiography. 
      Immediately after pPCI, QCA measurements of vessel size were smaller than OCT 
      with statistical significance: mean reference vessel diameter (RVD) was 
      respectively 3.1+/-0.4 versus 3.4+/-0.5 mm (P<0.001), mean minimum lumen diameter 
      (MLD) 2.5+/-0.3 versus 3.0+/-0.3 mm (P<0.001) and mean BVS diameter 2.8+/-0.3 versus 
      3.26+/-0.29 mm (P=0.001). Mean RVD and reference vessel area (RVA) were larger at 1 
      year CT angiography in comparison to baseline OCT (3.4+/-0.5 mm versus 3.76+/-0.45 
      mm, P=0.009, and 9.27+/-2.7 mm2 versus 11.28+/-2.62 mm2, P=0.01, respectively) and 
      MLD was also larger at follow-up: 2.96+/-0.29 mm versus 3.09+/-0.53 (P=0.077). 
      However, the mean percent area stenosis (parameter not influenced by possible 
      difference between different methods) measured with OCT immediately after pPCI 
      and with CT angiography at 1 year did not show any difference (20.2+/-23.9% versus 
      24.8+/-17.8%, P=0.478). CONCLUSIONS: In comparison with OCT, QCA largely 
      underestimates luminal diameters and may interfere with BVS proper sizing. CT 
      angiography did not identify any evidence of binary restenosis, confirming the 
      effective anti-restenotic properties of BVS at mid-term follow-up.
FAU - Marchese, Giuseppe
AU  - Marchese G
AD  - Department of Cardiology, University Hospital of Verona, Verona, Italy - 
      viktor.kocka@fnkv.cz.
FAU - Petr, Robert
AU  - Petr R
FAU - Tousek, Petr
AU  - Tousek P
FAU - Widimsky, Petr
AU  - Widimsky P
FAU - Kocka, Viktor
AU  - Kocka V
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160412
PL  - Italy
TA  - Minerva Cardioangiol
JT  - Minerva cardioangiologica
JID - 0400725
SB  - IM
MH  - Aged
MH  - Blood Vessel Prosthesis Implantation/*methods/mortality
MH  - Coronary Angiography
MH  - Drug-Eluting Stents
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging/*methods
MH  - Percutaneous Coronary Intervention/methods
MH  - Prospective Studies
MH  - ST Elevation Myocardial Infarction/diagnostic imaging/*surgery
MH  - Tomography, Optical Coherence
MH  - Tomography, X-Ray Computed
EDAT- 2016/04/14 06:00
MHDA- 2017/06/24 06:00
CRDT- 2016/04/13 06:00
PHST- 2016/04/13 06:00 [entrez]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2017/06/24 06:00 [medline]
AID - R05Y9999N00A16041201 [pii]
PST - ppublish
SO  - Minerva Cardioangiol. 2016 Aug;64(4):411-8. Epub 2016 Apr 12.