PMID- 27071288
OWN - NLM
STAT- MEDLINE
DCOM- 20160428
LR  - 20190918
IS  - 0042-8450 (Print)
IS  - 0042-8450 (Linking)
VI  - 73
IP  - 2
DP  - 2016 Feb
TI  - Percutaneous implantation of self-expandable aortic valve in high risk patients 
      with severe aortic stenosis: The first experiences in Serbia.
PG  - 192-7
AB  - BACKGROUND/AIM: Aortic stenosis (AS) is the most common valvular heart disease in 
      elderly people, with rather poor prognosis in symptomatic patients. Surgical 
      valve replacement is the therapy of choice, but a significant number of patients 
      cannot undergo surgical procedure. We presented initial experience of 
      transcatheter aortic valve implantation (TAVI) performed in Catheterization 
      Laboratory of the Clinic for Cardiology, Clinical Center of Serbia. METHODS: The 
      procedures were performed in 5 patients (mean age 76 +/- 6 years, 2 males, 3 
      female) with severe and symptomatic AS with contraindication to surgery or high 
      surgical risk. The decision to perform TAVI was made by the heart team. 
      Pre-procedure screening included detailed clinical and echocardiographic 
      evaluation, coronary angiography and computed tomography scan. In all the 
      patients we implanted a self-expandable aortic valve (Core Valve, Medtronic, 
      USA). Six months follow-up was available for all the patients. RESULTS: All 
      interventions were successfully performed without significant periprocedural 
      complications. Immediate hemodynamic improvement was obtained in all the patients 
      (peak gradient 94.2 +/- 27.6 to 17.6 +/- 5.2 mmHg, p < 0.001, mean pressure gradient 
      52.8 +/- 14.5 to 8.0 +/- 2.1 mmHg, p < 0.001). None of the patients developed heart 
      block, stroke, vascular complication or significant aortic regurgitation. After 6 
      months, the survival was 100% with New York Heart Association (NYHA) functional 
      improvement in all the patients. CONCLUSION: This successful initial experience 
      provides a solid basis to treat larger number of patients with symptomatic AS and 
      high surgical risk who are left untreated.
FAU - Nedeljkovic, Milan A
AU  - Nedeljkovic MA
FAU - Beleslin, Branko
AU  - Beleslin B
FAU - Tesic, Milorad
AU  - Tesic M
FAU - Vukcevic, Vladan
AU  - Vukcevic V
FAU - Stankovic, Goran
AU  - Stankovic G
FAU - Stojkovic, Sinisa
AU  - Stojkovic S
FAU - Orlic, Dejan
AU  - Orlic D
FAU - Bilbija, Ilija
AU  - Bilbija I
FAU - Matkovic, Milos
AU  - Matkovic M
FAU - Simic, Tijana
AU  - Simic T
FAU - Menkovic, Nemanja
AU  - Menkovic N
FAU - Mrdovic, Igor
AU  - Mrdovic I
FAU - Ussia, Gian Paolo
AU  - Ussia GP
FAU - Perisic, Zoran
AU  - Perisic Z
FAU - Babic, Momcilo
AU  - Babic M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Serbia
TA  - Vojnosanit Pregl
JT  - Vojnosanitetski pregled
JID - 21530700R
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve/*surgery
MH  - *Aortic Valve Stenosis/diagnosis/surgery
MH  - *Bioprosthesis
MH  - Coronary Angiography/methods
MH  - Echocardiography/methods
MH  - Female
MH  - *Heart Valve Prosthesis
MH  - Humans
MH  - Male
MH  - Prosthesis Design
MH  - Risk Adjustment
MH  - Serbia
MH  - Severity of Illness Index
MH  - Transcatheter Aortic Valve Replacement/*methods
MH  - Treatment Outcome
EDAT- 2016/04/14 06:00
MHDA- 2016/04/29 06:00
CRDT- 2016/04/14 06:00
PHST- 2016/04/14 06:00 [entrez]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2016/04/29 06:00 [medline]
AID - 10.2298/vsp141117024n [doi]
PST - ppublish
SO  - Vojnosanit Pregl. 2016 Feb;73(2):192-7. doi: 10.2298/vsp141117024n.