PMID- 27071516
OWN - NLM
STAT- MEDLINE
DCOM- 20170315
LR  - 20181202
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 39
IP  - 7
DP  - 2016 Jul
TI  - Late Gadolinium Enhancement in Patients with Nonischemic Dilated Cardiomyopathy.
PG  - 731-47
LID - 10.1111/pace.12873 [doi]
AB  - One-third of all patients with heart failure have nonischemic dilated 
      cardiomyopathy (NIDM). Five-year mortality from NIDM is as high as 20% with 
      sudden cardiac death (SCD) as the cause in 30% of the deaths. Currently, the left 
      ventricular ejection fraction (LVEF) is used as the main criteria to risk 
      stratify patients requiring an implantable cardioverter defibrillator (ICD) to 
      prevent SCD. However, LVEF does not necessarily reflect myocardial propensity for 
      electrical instability leading to ventricular tachycardia (VT) or ventricular 
      fibrillation (VF). Due to the differential risk in various subgroups of patients 
      for arrhythmic death, it is important to identify appropriate patients for ICD 
      implantation so that we can optimize healthcare resources and avoid the 
      complications of ICDs in individuals who are unlikely to benefit. We performed a 
      systematic search and review of clinical trials of NIDM and the use of ICDs and 
      cardiac magnetic resonance imaging with late gadolinium enhancement (LGE) for 
      risk stratification. LGE identifies patients with NIDM who are at high risk for 
      SCD and enables optimized patient selection for ICD placement, while the absence 
      of LGE may reduce the need for ICD implantation in patients with NIDM who are at 
      low risk for future VF/VT or SCD.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Memon, Sarfaraz
AU  - Memon S
AD  - Division of Cardiology, Hartford Hospital, Hartford, Connecticut.
FAU - Ganga, Harsha V
AU  - Ganga HV
AD  - Division of Cardiology, Brown University, Providence, Rhode Island.
FAU - Kluger, Jeffrey
AU  - Kluger J
AD  - Division of Cardiology, Hartford Hospital, Hartford, Connecticut.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20160519
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathy, Dilated/*diagnostic imaging/*mortality
MH  - Comorbidity
MH  - Contrast Media
MH  - Death, Sudden, Cardiac/*epidemiology
MH  - *Gadolinium
MH  - Heart Failure
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods/statistics & numerical data
MH  - Middle Aged
MH  - Prevalence
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Survival Rate
OTO - NOTNLM
OT  - cardiomyopathy
OT  - late gadolinium
OT  - sudden death
OT  - ventricular tachycardia
EDAT- 2016/04/14 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/04/14 06:00
PHST- 2015/07/22 00:00 [received]
PHST- 2016/03/22 00:00 [revised]
PHST- 2016/04/06 00:00 [accepted]
PHST- 2016/04/14 06:00 [entrez]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
AID - 10.1111/pace.12873 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2016 Jul;39(7):731-47. doi: 10.1111/pace.12873. Epub 
      2016 May 19.