PMID- 27072099
OWN - NLM
STAT- MEDLINE
DCOM- 20160909
LR  - 20160413
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 127
IP  - 5
DP  - 2016 May
TI  - Transcranial direct current stimulation over the left dorsolateral prefrontal 
      cortex modulates auditory mismatch negativity.
PG  - 2263-72
LID - S1388-2457(16)00064-X [pii]
LID - 10.1016/j.clinph.2016.01.024 [doi]
AB  - OBJECTIVE: To investigate the contribution of the left dorsolateral prefrontal 
      cortex (DLPFC) to attentive and pre-attentive stimulus discrimination via 
      transcranial direct current stimulation (tDCS). METHODS: Novelty- and target-P3 
      as indexes of attentive stimulus discrimination and the mismatch negativities 
      (MMNs) for duration, intensity, and frequency deviants as indexes of 
      pre-attentive stimulus discrimination were recorded before and after delivering 
      anodal and cathodal tDCS to the left DLPFC. RESULTS: MMN amplitudes for all kinds 
      of deviants decreased from pre- to post-tDCS measurement. For duration and 
      intensity deviants, this pre-post reduction was stronger after anodal tDCS, as 
      compared to the decrease after sham stimulation. No such modulation was found for 
      the MMN to frequency deviants. Neither the novelty-P3 nor the target-P3 was 
      modulated by tDCS. CONCLUSION: The selective MMN decrease after anodal 
      (excitatory) stimulation of the left DLPFC suggests that this region either 
      inhibits the processing of specific auditory changes or modulates the habituation 
      of the MMN to certain kinds of deviances. SIGNIFICANCE: Our finding that left 
      frontal anodal tDCS reduces the MMN to duration and intensity deviants further 
      highlights the contribution of frontal brain regions to MMN generation and 
      extends previous reports of reduced MMNs to frequency deviants after right 
      frontal anodal tDCS.
CI  - Copyright (c) 2016 International Federation of Clinical Neurophysiology. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Weigl, Michael
AU  - Weigl M
AD  - Department of Psychology, Experimental Neuropsychology Unit, Saarland University, 
      66041 Saarbrucken, Germany. Electronic address: m.weigl@mx.uni-saarland.de.
FAU - Mecklinger, Axel
AU  - Mecklinger A
AD  - Department of Psychology, Experimental Neuropsychology Unit, Saarland University, 
      66041 Saarbrucken, Germany.
FAU - Rosburg, Timm
AU  - Rosburg T
AD  - Department of Psychology, Experimental Neuropsychology Unit, Saarland University, 
      66041 Saarbrucken, Germany; Department of Forensic Psychiatry, University 
      Psychiatric Clinics, Wilhelm Klein-Str. 27, 4012 Basel, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160211
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Attention/*physiology
MH  - Electroencephalography
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Prefrontal Cortex/*physiology
MH  - *Transcranial Direct Current Stimulation
MH  - Young Adult
OTO - NOTNLM
OT  - Mismatch negativity (MMN)
OT  - Neuroplasticity
OT  - P300
OT  - Prefrontal cortex
OT  - Transcranial direct current stimulation (tDCS)
EDAT- 2016/04/14 06:00
MHDA- 2016/09/10 06:00
CRDT- 2016/04/14 06:00
PHST- 2015/09/28 00:00 [received]
PHST- 2016/01/21 00:00 [revised]
PHST- 2016/01/22 00:00 [accepted]
PHST- 2016/04/14 06:00 [entrez]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2016/09/10 06:00 [medline]
AID - S1388-2457(16)00064-X [pii]
AID - 10.1016/j.clinph.2016.01.024 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2016 May;127(5):2263-72. doi: 10.1016/j.clinph.2016.01.024. 
      Epub 2016 Feb 11.