PMID- 27073476
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 11
IP  - 4
DP  - 2016 Apr
TI  - Extracellular vesicles derived from mesenchymal stromal cells may possess 
      increased therapeutic potential for acute kidney injury compared with conditioned 
      medium in rodent models: A meta-analysis.
PG  - 1519-1525
AB  - The potential involvement of the endocrine/paracrine mechanisms in the 
      mesenchymal stromal cells (MSCs) therapy for acute kidney injury (AKI) has been 
      increasingly studied. The aim of the present meta-analysis was to systematically 
      review the therapeutic role of MSC-conditioned medium (CM) or MSCs released by 
      extracellular vesicles (Evs) for the treatment of AKI in rodent models. Studies 
      were identified using PubMed and Scopus databases using a custom search strategy 
      and eligibility criteria. Data regarding serum creatinine (SCr) concentration, CM 
      or Evs, measurement time point, AKI model (toxic or non-toxic) and other 
      parameters, including delivery route, animal type and animal numbers, were 
      extracted. Pooled analysis and subgroup analysis as well as multivariable 
      meta-regression were performed. Heterogeneity and publication bias were also 
      investigated. A total of 13 studies were included and analyzed. Pooled analysis 
      showed reduced SCr (0.93 [0.67, 1.20], mg/dl) in rodent models of AKI after 
      CM/Evs therapy. The results of the subgroup analysis suggested that Evs induced 
      an increased therapeutic effect, in the form of SCr reduction, as compared with 
      CM (P=0.05). There were also other significant influential factors for SCr 
      reduction including measurement time point (P=0.0004) and therapeutic time point 
      (P<0.0001) after surgery. By contrast, parameters such as delivery route, injury 
      type and cell type were not significant influential factors. Multivariable 
      meta-regression analysis showed that measurement time point (P=0.041), 
      therapeutic time point (P=0.03), Evs or CM (P=0.0003) and cell type (P<0.0001) 
      were influential factors in the reduction of SCr. The present meta-analysis 
      indicates that CM or Evs derived from MSCs are able to improve the impaired renal 
      function in rodents modelling AKI. Compared with CM, Evs may produce a more 
      marked therapeutic effect in recovery from renal failure. In addition, CM or Evs 
      administration in early stages of AKI may result in more evident effects.
FAU - Zhang, Guangyuan
AU  - Zhang G
AD  - Department of Urology, Shanghai First People's Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai 200080, P.R. China.
FAU - Wang, Dandan
AU  - Wang D
AD  - Department of Nephrology, The Second People's Hospital of Shenzhen, Guangzhou 
      Medical University, Shenzhen, Guangzhou, Guangdong 510182, P.R. China.
FAU - Miao, Shuai
AU  - Miao S
AD  - Department of Urology, Shanghai First People's Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai 200080, P.R. China.
FAU - Zou, Xiangyu
AU  - Zou X
AD  - Department of Urology, Shanghai First People's Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai 200080, P.R. China.
FAU - Liu, Guohua
AU  - Liu G
AD  - Department of Urology, Shanghai First People's Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai 200080, P.R. China.
FAU - Zhu, Yingjian
AU  - Zhu Y
AD  - Department of Urology, Shanghai First People's Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai 200080, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20160216
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC4812181
OTO - NOTNLM
OT  - acute kidney injury
OT  - conditioned medium
OT  - extracellular vesicles
OT  - mesenchymal stromal cells
OT  - meta-analysis
EDAT- 2016/04/14 06:00
MHDA- 2016/04/14 06:01
PMCR- 2016/02/16
CRDT- 2016/04/14 06:00
PHST- 2014/12/04 00:00 [received]
PHST- 2016/01/26 00:00 [accepted]
PHST- 2016/04/14 06:00 [entrez]
PHST- 2016/04/14 06:00 [pubmed]
PHST- 2016/04/14 06:01 [medline]
PHST- 2016/02/16 00:00 [pmc-release]
AID - ETM-0-0-3076 [pii]
AID - 10.3892/etm.2016.3076 [doi]
PST - ppublish
SO  - Exp Ther Med. 2016 Apr;11(4):1519-1525. doi: 10.3892/etm.2016.3076. Epub 2016 Feb 
      16.