PMID- 27073595
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160413
LR  - 20201001
IS  - 1944-8171 (Print)
IS  - 1944-8171 (Electronic)
IS  - 1944-8171 (Linking)
VI  - 7
IP  - 4
DP  - 2015
TI  - Association analysis of HLA-DRA in Chinese patients with sporadic Parkinson's 
      disease.
PG  - 185-94
AB  - Our aim is to explore the linkage between single nucleotide polymorphisms (SNPs) 
      in human leukocyte antigen (HLA)-DRA and Parkinson's disease (PD). 542 sporadic 
      PD patients and 674 healthy controls were recruited to investigate this 
      association in the Chinese population by the screening of 15 SNPs in HLA-DRA, and 
      the association of rs3129882 was further re-evaluated by performing meta-analysis 
      and meta-regression analysis. No SNPs in HLA-DRA were significantly associated 
      with PD in the Chinese patients. Although the rs3129882 allele-G frequency in the 
      Caucasian population was lower than that in Chinese population, meta-analysis 
      showed no association of rs3129882 allele-G with PD in the Chinese or Caucasian 
      population. In consideration of the heterogeneity (I(2)=78.6%, Q=66.33, p<0.000), 
      subgroup analysis was performed, revealing a significant association between 
      rs3129882 and PD in the Caucasian patients from the genome-wide association 
      studies (OR=1.22, 95% CI: 1.16, 1.27); however, this association was not 
      consistently observed in the studies performed using other DNA sequencing 
      techniques. Meta-regression analysis, which accounted for 58.3% of the 
      heterogeneity, revealed that the impact of the sequencing technique used was 
      significant (p=0.027) compared with ethnicity. Regression analysis of the 
      Caucasian population further showed that the sequencing technique used 
      contributed to 71.2% of the heterogeneity (p=0.033). Our data support the absence 
      of a linkage between the risk loci in HLA-DRA and PD in Chinese patients. The 
      different DNA sequencing techniques used in PD studies may largely account for 
      the controversial conclusions concerning rs3129882.
FAU - Mo, Ming-Shu
AU  - Mo MS
AD  - Department of Neurology, First Affiliated Hospital of Sun Yat-sen 
      UniversityGuangzhou 510000, China; Department of Neurology, First Affiliated 
      Hospital of Guangzhou Medical UniversityGuangdong 510120, China.
FAU - Xiao, You-Sheng
AU  - Xiao YS
AD  - Department of Neurology, First Affiliated Hospital of Sun Yat-sen University 
      Guangzhou 510000, China.
FAU - Wu, Zhuo-Hua
AU  - Wu ZH
AD  - Department of Neurology, First Affiliated Hospital of Guangzhou Medical 
      University Guangdong 510120, China.
FAU - Sun, Cong-Cong
AU  - Sun CC
AD  - Department of Neurology, First Affiliated Hospital of Sun Yat-sen 
      UniversityGuangzhou 510000, China; Department of Neurology, QiLu Hospital of 
      Shandong UniversityJinan 250000, China.
FAU - Zhang, Li-Min
AU  - Zhang LM
AD  - Department of Neurology, First Affiliated Hospital of Sun Yat-sen University 
      Guangzhou 510000, China.
FAU - Cen, Luan
AU  - Cen L
AD  - Department of Neurology, First Affiliated Hospital of Sun Yat-sen University 
      Guangzhou 510000, China.
FAU - Chen, Xiang
AU  - Chen X
AD  - Department of Neurology, First Affiliated Hospital of Sun Yat-sen University 
      Guangzhou 510000, China.
FAU - Qu, Shao-Gang
AU  - Qu SG
AD  - Department of Immunology, School of Basic Medical Sciences, Southern Medical 
      University Guangzhou 510515, China.
FAU - Yang, Xin-Ling
AU  - Yang XL
AD  - Department of Neurology, Second Affiliated Hospital of Xinjiang Medical 
      University Urumqi 830011, China.
FAU - Xu, Ping-Yi
AU  - Xu PY
AD  - Department of Neurology, First Affiliated Hospital of Guangzhou Medical 
      University Guangdong 510120, China.
LA  - eng
PT  - Journal Article
DEP - 20151225
PL  - United States
TA  - Int J Physiol Pathophysiol Pharmacol
JT  - International journal of physiology, pathophysiology and pharmacology
JID - 101521074
PMC - PMC4788728
OTO - NOTNLM
OT  - DNA sequencing analysis
OT  - HLA-DRA
OT  - Parkinson's disease
EDAT- 2015/01/01 00:00
MHDA- 2015/01/01 00:01
PMCR- 2015/12/25
CRDT- 2016/04/14 06:00
PHST- 2015/12/23 00:00 [received]
PHST- 2015/12/24 00:00 [accepted]
PHST- 2016/04/14 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2015/01/01 00:01 [medline]
PHST- 2015/12/25 00:00 [pmc-release]
PST - epublish
SO  - Int J Physiol Pathophysiol Pharmacol. 2015 Dec 25;7(4):185-94. eCollection 2015.