PMID- 2707922
OWN - NLM
STAT- MEDLINE
DCOM- 19890601
LR  - 20131121
IS  - 0251-1649 (Print)
IS  - 0251-1649 (Linking)
VI  - 9
IP  - 1
DP  - 1989
TI  - Ibopamine: long-term safety study in patients with congestive heart failure. The 
      Italian Ibopamine Working Group.
PG  - 21-8
AB  - Ibopamine is a new orally active dopamine analogue with positive inotropic and 
      vasodilating activity. The tolerability of the drug administered at the dose of 
      100 mg thrice daily for 12 months was studied in 302 patients with congestive 
      heart failure, New York Heart Association (NYHA) class II and III. Of the 302 
      patients, 198 completed the study (65%); 59 patients (19%) were withdrawn for 
      clinical events; 27 of them died (9%); 35 patients (12%) did not complete the 
      study for non-compliance and 10 (3%) for protocol violations. Clinical events 
      were generally related to the cardiovascular system and 85% of deaths were from 
      cardiovascular causes. None of the deaths was considered related to treatment by 
      the investigators. Clinically significant laboratory abnormalities were observed 
      during the study in four patients only. This trial suggests that ibopamine is 
      well tolerated in patients with congestive heart failure, NYHA class II and III, 
      at the dose of 100 mg thrice daily for up to one year.
FAU - Riva, E
AU  - Riva E
AD  - Smith Kline and French, Clinical Research and Development, Milan, Italy.
FAU - Cavalli, A
AU  - Cavalli A
FAU - Abbondati, G
AU  - Abbondati G
FAU - Cedrini, M C
AU  - Cedrini MC
FAU - Schleman, M
AU  - Schleman M
FAU - Fuccella, L M
AU  - Fuccella LM
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Int J Clin Pharmacol Res
JT  - International journal of clinical pharmacology research
JID - 8110183
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Diuretics)
RN  - 0 (Vasodilator Agents)
RN  - 8ZCA2I2L11 (ibopamine)
RN  - R7339QLN1C (Deoxyepinephrine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiotonic Agents/*administration & dosage
MH  - Demography
MH  - Deoxyepinephrine/administration & dosage/*analogs & derivatives
MH  - Diuretics/*administration & dosage
MH  - Dopamine/*analogs & derivatives
MH  - Drug Tolerance
MH  - Female
MH  - Heart Failure/*drug therapy
MH  - Humans
MH  - Kidney Function Tests
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Time Factors
MH  - Vasodilator Agents/*administration & dosage
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PST - ppublish
SO  - Int J Clin Pharmacol Res. 1989;9(1):21-8.