PMID- 27079418
OWN - NLM
STAT- MEDLINE
DCOM- 20170316
LR  - 20181202
IS  - 1724-6040 (Electronic)
IS  - 0391-3988 (Linking)
VI  - 39
IP  - 3
DP  - 2016 May 16
TI  - First report of cytokine removal using CytoSorb(R) in severe noninfectious 
      inflammatory syndrome after liver transplantation.
PG  - 136-40
LID - 10.5301/ijao.5000489 [doi]
AB  - INTRODUCTION: Emergency transplantation of a donor liver that is not matched for 
      the major blood antigens can produce marked immune-mediated cytokine release that 
      can cause donor graft loss. Control of the inflammatory response may be a key 
      element in treatment. METHODS: We present the case of a 46-year-old man with 
      primary graft nonfunction after liver transplantation who underwent emergency 
      retransplantation with an ABO-incompatible graft. A severe inflammatory response 
      syndrome (SIRS) was noted in the perioperioperative period of retransplantation. 
      The patient was successfully treated for this condition with a new hemoadsorption 
      column (CytoSorb(R)), in combination with continuous venovenous hemofiltration 
      (CVVH) throughout the intraoperative and early postoperative period. RESULTS: 
      During and after each treatment a significant and rapid decrease of pro- and 
      anti-inflammatory cytokines was observed, especially for interleukin-6 (IL-6), 
      IL-10 and monocyte chemotactic protein 1 (MCP-1). Reduction of cytokines was 
      associated with normalization of cardiac output and systemic vascular resistance, 
      and improved liver function. CONCLUSIONS: We believe this is the first case in 
      which hemoadsorptionin combination with CVVH has been used to manage SIRS in a 
      patient with primary graft nonfunction undergoing emergency retransplantation.
FAU - Tomescu, Dana R
AU  - Tomescu DR
AD  - Department of Anesthesiology and Critical Care III, Fundeni Clinical Institute, 
      Bucharest - Romania.
AD  - University of Medicine and Pharmacy "Carol Davila", Bucharest - Romania.
FAU - Olimpia Dima, Simona
AU  - Olimpia Dima S
AD  - Department of General Surgery and Liver Transplantation, Fundeni Clinical 
      Institute, Bucharest - Romania.
FAU - Ungureanu, Daniela
AU  - Ungureanu D
AD  - Department of Anesthesiology and Critical Care I, Fundeni Clinical Institute, 
      Bucharest - Romania.
FAU - Popescu, Mihai
AU  - Popescu M
AD  - University of Medicine and Pharmacy "Carol Davila", Bucharest - Romania.
FAU - Tulbure, Dan
AU  - Tulbure D
AD  - University of Medicine and Pharmacy "Carol Davila", Bucharest - Romania.
AD  - Department of Anesthesiology and Critical Care I, Fundeni Clinical Institute, 
      Bucharest - Romania.
FAU - Popescu, Irinel
AU  - Popescu I
AD  - University of Medicine and Pharmacy "Carol Davila", Bucharest - Romania.
AD  - Department of General Surgery and Liver Transplantation, Fundeni Clinical 
      Institute, Bucharest - Romania.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160414
PL  - United States
TA  - Int J Artif Organs
JT  - The International journal of artificial organs
JID - 7802649
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adsorption
MH  - Chemokine CCL2/blood
MH  - Cytokines/*blood
MH  - Graft Rejection/blood/*surgery
MH  - Hemofiltration/*methods
MH  - Humans
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Liver Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Reoperation
MH  - Systemic Inflammatory Response Syndrome/blood/etiology/*therapy
MH  - Tissue Donors
MH  - Treatment Outcome
EDAT- 2016/04/16 06:00
MHDA- 2017/03/17 06:00
CRDT- 2016/04/16 06:00
PHST- 2016/03/27 00:00 [accepted]
PHST- 2016/04/16 06:00 [entrez]
PHST- 2016/04/16 06:00 [pubmed]
PHST- 2017/03/17 06:00 [medline]
AID - 0AF81E76-667B-44FA-B5F6-ED62949C356D [pii]
AID - 10.5301/ijao.5000489 [doi]
PST - ppublish
SO  - Int J Artif Organs. 2016 May 16;39(3):136-40. doi: 10.5301/ijao.5000489. Epub 
      2016 Apr 14.