PMID- 27079619
OWN - NLM
STAT- MEDLINE
DCOM- 20170323
LR  - 20221207
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 34
DP  - 2016 Aug
TI  - Contractile effects of 3,4-methylenedioxymethamphetamine on the human internal 
      mammary artery.
PG  - 187-193
LID - S0887-2333(16)30069-8 [pii]
LID - 10.1016/j.tiv.2016.04.002 [doi]
AB  - Since the late 1980s numerous reports have detailed adverse reactions to the use 
      of 3,4-methylenedioxymethamphetamine (MDMA) associated with cardiovascular 
      collapse and sudden death, following ventricular tachycardia and hypertension. 
      For a better understanding of the effects of MDMA on the cardiovascular system, 
      it is critical to determine their effects at the vasculature level, including the 
      transporter or neurotransmitter systems that are most affected at the whole range 
      of drug doses. With this purpose in mind, the aim of our study was to evaluate 
      the contractile effect of MDMA in the human internal mammary artery, the 
      contribution of SERT for this effect and the responsiveness of this artery to 
      5-HT in the presence of MDMA. We have also studied the possible involvement of 
      5-HT2 receptors on the MDMA contractile effect in this human blood vessel using 
      ketanserin. Our results showed that MDMA contracted the studied human's internal 
      mammary artery in a SERT-independent form, through activation of 5-HT2A 
      receptors. Considering the high plasma concentrations achieved in heavy users or 
      in situations of acute exposure to drugs, this effect is probably involved in the 
      cardiovascular risk profile of this psychostimulant, especially in subjects with 
      pre-existing cardiovascular disease.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Silva, Sonia
AU  - Silva S
AD  - Group of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of 
      Coimbra, Portugal. Electronic address: sonias@ci.uc.pt.
FAU - Carvalho, Felix
AU  - Carvalho F
AD  - UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, 
      Faculty of Pharmacy, University of Porto, Portugal.
FAU - Fernandes, Eduarda
AU  - Fernandes E
AD  - UCIBIO-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemistry, 
      Faculty of Pharmacy, University of Porto, Portugal.
FAU - Antunes, Manuel J
AU  - Antunes MJ
AD  - Cardiothoracic Surgery, University Hospital of Coimbra, Coimbra, Portugal.
FAU - Cotrim, Maria Dulce
AU  - Cotrim MD
AD  - Group of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of 
      Coimbra, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20160411
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with 
      BIBRA
JID - 8712158
RN  - 0 (Hallucinogens)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Receptor, Serotonin, 5-HT2C)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 333DO1RDJY (Serotonin)
RN  - 97F9DE4CT4 (Ketanserin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Fluoxetine/pharmacology
MH  - Hallucinogens/*pharmacology
MH  - Humans
MH  - In Vitro Techniques
MH  - Isometric Contraction/drug effects
MH  - Ketanserin/pharmacology
MH  - Mammary Arteries/*drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Receptor, Serotonin, 5-HT2A/*physiology
MH  - Receptor, Serotonin, 5-HT2C/physiology
MH  - Serotonin/pharmacology
MH  - Serotonin Antagonists/pharmacology
MH  - Serotonin Plasma Membrane Transport Proteins/physiology
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
OTO - NOTNLM
OT  - 5-HT
OT  - Fluoxetine
OT  - Human internal mammary artery
OT  - Ketanserin
OT  - MDMA (ecstasy)
EDAT- 2016/04/16 06:00
MHDA- 2017/03/24 06:00
CRDT- 2016/04/16 06:00
PHST- 2015/09/29 00:00 [received]
PHST- 2016/03/24 00:00 [revised]
PHST- 2016/04/04 00:00 [accepted]
PHST- 2016/04/16 06:00 [entrez]
PHST- 2016/04/16 06:00 [pubmed]
PHST- 2017/03/24 06:00 [medline]
AID - S0887-2333(16)30069-8 [pii]
AID - 10.1016/j.tiv.2016.04.002 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2016 Aug;34:187-193. doi: 10.1016/j.tiv.2016.04.002. Epub 2016 
      Apr 11.