PMID- 27079773
OWN - NLM
STAT- MEDLINE
DCOM- 20170503
LR  - 20220410
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 115
IP  - 12
DP  - 2016 Jun
TI  - Supplementation of branched-chain amino acids to a reduced-protein diet improves 
      growth performance in piglets: involvement of increased feed intake and direct 
      muscle growth-promoting effect.
PG  - 2236-45
LID - 10.1017/S0007114516000842 [doi]
AB  - The aim of this study was to investigate whether supplementing branched-chain 
      amino acids (AA) (BCAA) along with a reduced-protein diet increases piglet 
      growth, and whether elevated feed intake and muscle growth-promoting effect 
      contribute to this improvement. In Expt 1, twenty-eight weanling piglets were 
      randomly fed one of the following four diets: a positive control (PC) diet, a 
      reduced-protein negative control (NC) diet, an NC diet supplemented with BCAA to 
      the same levels as in the PC diet (test 1 (T1)) and an NC diet supplemented with 
      a 2-fold dose of BCAA in T1 diet (test 2 (T2)) for 28 d. In Expt 2, twenty-one 
      weanling piglets were randomly assigned to NC, T1 and pair-fed T1 (P) groups. NC 
      and T1 diets were the same as in Expt 1, whereas piglets in the P group were 
      individually pair-fed with the NC group. In Expt 1, the NC group had reduced 
      piglet growth and feed intake compared with the PC group, which were restored in 
      T1 and T2 groups, but no differences were detected between T1 and T2 groups. In 
      Expt 2, T1 and P groups showed increases in growth and mass of some muscles 
      compared with the NC group. Increased feed intake after BCAA supplementation was 
      associated with increased mRNA expressions of agouti-related peptide and 
      co-express neuropeptide Y (NPY) and phosphorylation of mammalian target of 
      rapamycin (mTOR) and ribosomal protein S6 kinase 1 (S6K1), as well as decreased 
      mRNA expressions of melanocortin-4 receptor and cocaine- and 
      amphetamine-regulated transcript and phosphorylation of eukaryotic initiation 
      factor 2alpha in the hypothalamus. No differences were observed among PC, T1 and T2 
      groups except for higher NPY mRNA expression in the T2 group than in the PC group 
      (Expt 1). Phosphorylation of mTOR and S6K1 in muscle was enhanced after BCAA 
      supplementation, which was independent of change in feed intake (Expt 2). In 
      conclusion, supplementing BCAA to reduced-protein diets increases feed intake and 
      muscle mass, and contributes to better growth performance in piglets.
FAU - Zheng, Liufeng
AU  - Zheng L
AD  - 1Department of Animal Nutrition and Feed Science,College of Animal Science and 
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of 
      China.
FAU - Wei, Hongkui
AU  - Wei H
AD  - 1Department of Animal Nutrition and Feed Science,College of Animal Science and 
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of 
      China.
FAU - Cheng, Chuanshang
AU  - Cheng C
AD  - 1Department of Animal Nutrition and Feed Science,College of Animal Science and 
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of 
      China.
FAU - Xiang, Quanhang
AU  - Xiang Q
AD  - 1Department of Animal Nutrition and Feed Science,College of Animal Science and 
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of 
      China.
FAU - Pang, Jiaman
AU  - Pang J
AD  - 1Department of Animal Nutrition and Feed Science,College of Animal Science and 
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of 
      China.
FAU - Peng, Jian
AU  - Peng J
AD  - 1Department of Animal Nutrition and Feed Science,College of Animal Science and 
      Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160415
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Amino Acids, Branched-Chain)
SB  - IM
MH  - Amino Acids, Branched-Chain/*pharmacology
MH  - Animal Feed
MH  - Animal Husbandry
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Appetite/genetics
MH  - Brain/metabolism
MH  - *Diet, Protein-Restricted
MH  - *Dietary Supplements
MH  - Eating/*drug effects
MH  - Energy Intake/*drug effects
MH  - Male
MH  - Muscles/*drug effects/metabolism
MH  - Random Allocation
MH  - Swine/*growth & development
MH  - Weaning
MH  - Weight Gain
OTO - NOTNLM
OT  - AA amino acids
OT  - ADFI average daily feed intake
OT  - ADG average daily gain
OT  - BCAA branched-chain AA
OT  - BW body weight
OT  - Branched-chain amino acids
OT  - CART cocaine- and amphetamine-regulated transcript
OT  - CP crude protein
OT  - Feed intakes
OT  - G:F gain:feed intake
OT  - GAAC general amino acids control
OT  - Growth performance
OT  - LD longissimus dorsi
OT  - MC4R melanocortin-4 receptor
OT  - Muscle mass
OT  - NC reduced-protein negative control
OT  - NPY co-express neuropeptide Y
OT  - P pair-fed T1
OT  - PC positive control
OT  - Piglets
OT  - S6K1 ribosomal protein S6 kinase 1
OT  - T1 test 1
OT  - T2 test 2
OT  - eIF2alpha eukaryotic initiation factor 2alpha
OT  - mTOR mammalian target of rapamycin
EDAT- 2016/04/16 06:00
MHDA- 2017/05/04 06:00
CRDT- 2016/04/16 06:00
PHST- 2016/04/16 06:00 [entrez]
PHST- 2016/04/16 06:00 [pubmed]
PHST- 2017/05/04 06:00 [medline]
AID - S0007114516000842 [pii]
AID - 10.1017/S0007114516000842 [doi]
PST - ppublish
SO  - Br J Nutr. 2016 Jun;115(12):2236-45. doi: 10.1017/S0007114516000842. Epub 2016 
      Apr 15.