PMID- 27079805
OWN - NLM
STAT- MEDLINE
DCOM- 20170125
LR  - 20170125
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 94
IP  - 7
DP  - 2016 Nov
TI  - Choroidal circulation impairment during the anterior recurrence of 
      Vogt-Koyanagi-Harada disease confirmed with indocyanine green angiography and 
      laser speckle flowgraphy.
PG  - e629-e636
LID - 10.1111/aos.13024 [doi]
AB  - PURPOSE: To assess choroidal inflammation-related circulatory changes associated 
      with the anterior recurrence of Vogt-Koyanagi-Harada (VKH) disease, using 
      indocyanine green angiography (ICGA) and laser speckle flowgraphy (LSFG). 
      METHODS: This retrospective case series included 17 eyes of 11 patients with VKH 
      disease showing recurrent inflammatory findings in the anterior, but not 
      posterior, segment (i.e. anterior recurrence). Indocyanine green angiography 
      (ICGA) and LSFG were performed at the time of recurrence and one month after the 
      initiation of corticosteroid therapy. The number and total area of 
      hypofluorescent dark dots (HDDs) on ICGA were independently counted by three 
      physicians and measured with ImageJ, respectively. Mean blur rate (MBR), a 
      quantitative index of relative blood flow velocity, was calculated via the LSFG 
      Analyzer software. RESULTS: Hypofluorescent dark dots (HDDs) were identified on 
      ICGA in 13 of 17 eyes (76%) with the anterior recurrence of VKH disease. The 
      number and total area of HDDs significantly decreased from 203 +/- 101 dots to 
      59 +/- 51 dots and from 48 789 +/- 24 251 pixels to 15 664 +/- 13 254 pixels, 
      respectively. The change ratio of MBR significantly increased by 17.9 +/- 16.3% 
      after the treatment. Importantly, there was no significant association between 
      the change ratios of HDDs and MBR. CONCLUSIONS: These findings on LSFG and ICGA 
      clearly demonstrated subclinical involvement as well as post-treatment 
      improvement of choroidal circulation impairment due to granulomatous inflammation 
      in eyes with the anterior recurrence of VKH disease. The present data suggest the 
      validity of using these two examinations, capable of detecting different 
      circulatory changes, in the management of recurrent VKH disease.
CI  - (c) 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Takemoto, Yuko
AU  - Takemoto Y
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
AD  - Department of Ophthalmology and Visual Science, Kanazawa University Graduate 
      School of Medicine, Kanazawa, Japan.
FAU - Namba, Kenichi
AU  - Namba K
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan. knamba@med.hokudai.ac.jp.
FAU - Mizuuchi, Kazuomi
AU  - Mizuuchi K
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Iwata, Daiju
AU  - Iwata D
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Uno, Tomoe
AU  - Uno T
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Ohno, Shigeaki
AU  - Ohno S
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Hirooka, Kiriko
AU  - Hirooka K
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Hashimoto, Yuki
AU  - Hashimoto Y
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
FAU - Saito, Wataru
AU  - Saito W
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
AD  - Department of Ocular Circulation and Metabolism, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Sugiyama, Kazuhisa
AU  - Sugiyama K
AD  - Department of Ophthalmology and Visual Science, Kanazawa University Graduate 
      School of Medicine, Kanazawa, Japan.
FAU - Ishida, Susumu
AU  - Ishida S
AD  - Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan.
AD  - Department of Ocular Circulation and Metabolism, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160415
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anterior Eye Segment/*physiopathology
MH  - Blood Flow Velocity
MH  - Choroid/*blood supply
MH  - Coloring Agents/*administration & dosage
MH  - Female
MH  - Humans
MH  - Indocyanine Green/*administration & dosage
MH  - *Laser-Doppler Flowmetry
MH  - Male
MH  - Microcirculation
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Uveomeningoencephalitic Syndrome/diagnosis/*physiopathology
OTO - NOTNLM
OT  - Vogt-Koyanagi-Harada disease
OT  - anterior recurrence
OT  - choroidal circulation
OT  - hypofluorescent dark dots
OT  - indocyanine green angiography
OT  - laser speckle flowgraphy
OT  - mean blur rate
EDAT- 2016/10/19 06:00
MHDA- 2017/01/26 06:00
CRDT- 2016/04/16 06:00
PHST- 2015/04/29 00:00 [received]
PHST- 2016/01/23 00:00 [accepted]
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2017/01/26 06:00 [medline]
PHST- 2016/04/16 06:00 [entrez]
AID - 10.1111/aos.13024 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2016 Nov;94(7):e629-e636. doi: 10.1111/aos.13024. Epub 2016 Apr 
      15.