PMID- 27080916
OWN - NLM
STAT- MEDLINE
DCOM- 20170816
LR  - 20181202
IS  - 1557-900X (Electronic)
IS  - 0892-7790 (Linking)
VI  - 30
IP  - 7
DP  - 2016 Jul
TI  - Tamsulosin or Silodosin Adjuvant Treatment Is Ineffective in Improving Shockwave 
      Lithotripsy Outcome: A Short-Term Follow-Up Randomized, Placebo-Controlled Study.
PG  - 817-21
LID - 10.1089/end.2016.0113 [doi]
AB  - INTRODUCTION: The role of alpha-blockers after shockwave lithotripsy (SWL) is 
      controversial. The aim of our study was to evaluate the effect of tamsulosin and 
      silodosin after SWL for kidney stones. METHODS: From 2012 onward, a consecutive 
      series of patients undergoing SWL were prospectively enrolled and randomized by 
      closed envelopes in three groups receiving tamsulosin 0.4 mg (A), silodosin 8 mg 
      (B), and placebo (C) daily for 21 days after SWL. Anthropometrics, stone size, 
      and location were recorded before SWL. Visual analogue scale (VAS) score was 
      collected at 6, 12, and 24 hours after treatment to evaluate patients' 
      discomfort. Stone-free rate was assessed 1 and 3 weeks postoperatively. 
      Complications and medical treatment-related adverse events (AEs) were recorded. 
      Differences in VAS score, stone-free rate, and complications were compared among 
      the groups. RESULTS: Overall, 60 patients were enrolled. Mean stone sizes were 
      10.28 +/- 2.46 mm, 10.45 +/- 1.73 mm, and 9.23 +/- 2.04 mm in groups A, B, and C, 
      respectively (p = 0.474). There was no significant difference between the three 
      groups with regard to stone location. Comparable energy was used to treat 
      patients from the three groups. The overall 3-week stone-free rate was 53%: 58% 
      in the tamsulosin group, 47% in the silodosin group, and 55% in the placebo group 
      (p = 0.399). No significant differences were observed in the VAS scores reported 
      by the groups at 6 hours (p = 1.254), 12 hours (p = 0.075), and 24 hours 
      (p = 0.490). Overall, 12 complications were reported: 11 patients (7 in group C 
      and 4 in group B) needed analgesics for colic, and 1 patient (group B) was 
      surgically treated for Steinstrasse. Tamsulosin was superior to placebo 
      (p = 0.008) and silodosin (p = 0.021) in preventing complications; no difference 
      between silodosin and placebo (p = 0.629) was noted. CONCLUSIONS: Tamsulosin and 
      silodosin are ineffective in increasing stone-free rate as well as early 
      patients' discomfort after extracorporeal lithotripsy.
FAU - De Nunzio, Cosimo
AU  - De Nunzio C
AD  - Department of Urology, Sant'Andrea Hospital, "Sapienza", University of Rome , 
      Rome, Italy .
FAU - Brassetti, Aldo
AU  - Brassetti A
AD  - Department of Urology, Sant'Andrea Hospital, "Sapienza", University of Rome , 
      Rome, Italy .
FAU - Bellangino, Mariangela
AU  - Bellangino M
AD  - Department of Urology, Sant'Andrea Hospital, "Sapienza", University of Rome , 
      Rome, Italy .
FAU - Trucchi, Alberto
AU  - Trucchi A
AD  - Department of Urology, Sant'Andrea Hospital, "Sapienza", University of Rome , 
      Rome, Italy .
FAU - Petta, Stefano
AU  - Petta S
AD  - Department of Urology, Sant'Andrea Hospital, "Sapienza", University of Rome , 
      Rome, Italy .
FAU - Presicce, Fabrizio
AU  - Presicce F
AD  - Department of Urology, Sant'Andrea Hospital, "Sapienza", University of Rome , 
      Rome, Italy .
FAU - Tubaro, Andrea
AU  - Tubaro A
AD  - Department of Urology, Sant'Andrea Hospital, "Sapienza", University of Rome , 
      Rome, Italy .
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160511
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Analgesics)
RN  - 0 (Indoles)
RN  - 0 (Sulfonamides)
RN  - 0 (Urological Agents)
RN  - CUZ39LUY82 (silodosin)
RN  - G3P28OML5I (Tamsulosin)
SB  - IM
MH  - Adrenergic alpha-Antagonists/therapeutic use
MH  - Adult
MH  - Aged
MH  - Analgesics/therapeutic use
MH  - Chemotherapy, Adjuvant
MH  - Combined Modality Therapy
MH  - Double-Blind Method
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Indoles/*therapeutic use
MH  - Kidney Calculi/*therapy
MH  - Lithotripsy/adverse effects/*methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Renal Colic/drug therapy/etiology
MH  - Sulfonamides/*therapeutic use
MH  - Tamsulosin
MH  - Treatment Outcome
MH  - Ureterolithiasis/etiology
MH  - Urological Agents/*therapeutic use
EDAT- 2016/04/16 06:00
MHDA- 2017/08/17 06:00
CRDT- 2016/04/16 06:00
PHST- 2016/04/16 06:00 [entrez]
PHST- 2016/04/16 06:00 [pubmed]
PHST- 2017/08/17 06:00 [medline]
AID - 10.1089/end.2016.0113 [doi]
PST - ppublish
SO  - J Endourol. 2016 Jul;30(7):817-21. doi: 10.1089/end.2016.0113. Epub 2016 May 11.