PMID- 27082105
OWN - NLM
STAT- MEDLINE
DCOM- 20180427
LR  - 20180427
IS  - 1744-5078 (Electronic)
IS  - 0927-3948 (Linking)
VI  - 25
IP  - 4
DP  - 2017 Aug
TI  - Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome 
      Analyzed Using Spectral Domain Optical Coherence Tomography.
PG  - 545-553
LID - 10.3109/09273948.2016.1158841 [doi]
AB  - PURPOSE: To analyze sequential chorioretinal changes in presumed ocular 
      histoplasmosis syndrome (POHS) using volumetric spectral-domain optical coherence 
      tomography (SD-OCT). METHODS: A total of 28 treatment-naive eyes of 20 POHS 
      patients were characterized as: no choroidal neovascular membrane (CNVM) at 
      initial SD-OCT but CNVM development during follow-up (primary group); CNVM at 
      initial SD-OCT (progressive group); and contralateral asymptomatic eyes (control 
      group). RESULTS: The primary group (4/28 eyes) initially demonstrated external 
      limiting membrane (ELM), ellipsoid zone and retinal pigment epithelium 
      (RPE)/Bruch's disruption in 100%, and pigment epithelial detachment (PED) in 75% 
      of eyes. CNVM developed in 100% of eyes during follow-up. Progressive group (8/28 
      eyes) showed CNVM in 100% of eyes. Control group (16/28 eyes) showed ELM 
      disruption in two and PED in three additional eyes on follow-up from initial 
      analysis. CONCLUSIONS: SD-OCT is a useful tool to sequentially follow eyes with 
      POHS for subtle chorioretinal changes that may suggest impending CNVM 
      development, and thus benefit from closer clinical monitoring.
FAU - Adhi, Mehreen
AU  - Adhi M
AD  - a Department of Ophthalmology and Visual Sciences , Kentucky Lions Eye Center, 
      University of Louisville School of Medicine , Louisville , Kentucky , USA.
FAU - Jusufbegovic, Denis
AU  - Jusufbegovic D
AD  - a Department of Ophthalmology and Visual Sciences , Kentucky Lions Eye Center, 
      University of Louisville School of Medicine , Louisville , Kentucky , USA.
FAU - Schaal, Shlomit
AU  - Schaal S
AD  - a Department of Ophthalmology and Visual Sciences , Kentucky Lions Eye Center, 
      University of Louisville School of Medicine , Louisville , Kentucky , USA.
LA  - eng
PT  - Journal Article
DEP - 20160415
PL  - England
TA  - Ocul Immunol Inflamm
JT  - Ocular immunology and inflammation
JID - 9312169
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/*pathology
MH  - Choroidal Neovascularization/*diagnosis
MH  - Eye Infections, Fungal/*diagnosis
MH  - Female
MH  - Histoplasmosis/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retina/*pathology
MH  - Retinal Detachment/*diagnosis
MH  - Retinal Pigment Epithelium/*pathology
MH  - Tomography, Optical Coherence/methods
MH  - Young Adult
OTO - NOTNLM
OT  - Choroidal neovascular membrane
OT  - histo spots
OT  - pigment epithelial detachment
OT  - presumed ocular histoplasmosis syndrome
OT  - spectral-domain optical coherence tomography
EDAT- 2016/04/16 06:00
MHDA- 2018/04/28 06:00
CRDT- 2016/04/16 06:00
PHST- 2016/04/16 06:00 [pubmed]
PHST- 2018/04/28 06:00 [medline]
PHST- 2016/04/16 06:00 [entrez]
AID - 10.3109/09273948.2016.1158841 [doi]
PST - ppublish
SO  - Ocul Immunol Inflamm. 2017 Aug;25(4):545-553. doi: 10.3109/09273948.2016.1158841. 
      Epub 2016 Apr 15.