PMID- 27082305
OWN - NLM
STAT- MEDLINE
DCOM- 20160823
LR  - 20190110
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 4
DP  - 2016 Apr
TI  - Macular Structure and Function in Nonhuman Primate Experimental Glaucoma.
PG  - 1892-900
LID - 10.1167/iovs.15-18119 [doi]
AB  - PURPOSE: To evaluate structure and function of macular retinal layers in nonhuman 
      primate (NHP) experimental glaucoma (EG). METHODS: Twenty-one NHP had 
      longitudinal imaging of macular structure by SDOCT, 16 also had recordings of 
      function by multifocal ERG. The average thickness over 15 degrees  was derived for seven 
      individual SDOCT layers: macular nerve fiber layer (m-NFL), retinal ganglion cell 
      layer (RGCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer 
      plexiform layer (OPL), outer nuclear layer+inner segments combined (ONL+IS), and 
      outer segments (OS). Peripapillary RNFL thickness (ppRNFLT) was measured from a 
      single circular B-scan with 12 degrees  diameter. Responses to a slow-sequence multifocal 
      ERG (mfERG) stimulus (7F) were filtered (at 75 Hz) into low- and high-frequency 
      components (LFC, HFC). RESULTS: At final follow-up, significant structural loss 
      occurred only in EG eyes and only for ppRNFLT (-29 +/- 23%), m-NFL (-17 +/- 16%), 
      RGCL (-22 +/- 15%), and IPL (-19 +/- 14%); though there was also a small increase in 
      OPL (+6 +/- 7%) and ONL+IS (4 +/- 4%) and a similar tendency for INL. Macular 
      structural loss was correlated with ppRNFLT only for the NFL, RGCL and IPL (R = 
      0.95, 0.93 and 0.95, respectively, P < 0.0001). Significant functional loss 
      occurred only for HFC and N2 in EG eyes. Significant longitudinal 
      structure-function correlations (P < 0.01) were observed only in EG eyes and only 
      for mfERG HFC and N2: HFC was correlated with ppRNFLT (R = 0.69), macular NFL (R 
      = 0.67), RGCL (R = 0.74), and IPL (R = 0.72); N2 was correlated with RGCL (R = 
      0.54) and IPL (R = 0.48). High-frequency components amplitude change was 
      inversely correlated with outer retinal thickness change (= -0.66). CONCLUSIONS: 
      Macular structural and functional losses are correlated and specific to ganglion 
      cells over a wide range of EG severity. Outer retinal changes are likely due to 
      inner retinal loss.
FAU - Wilsey, Laura J
AU  - Wilsey LJ
FAU - Reynaud, Juan
AU  - Reynaud J
FAU - Cull, Grant
AU  - Cull G
FAU - Burgoyne, Claude F
AU  - Burgoyne CF
FAU - Fortune, Brad
AU  - Fortune B
LA  - eng
GR  - R01-EY021281/EY/NEI NIH HHS/United States
GR  - R01-EY011610/EY/NEI NIH HHS/United States
GR  - R01 EY021281/EY/NEI NIH HHS/United States
GR  - R01-EY019327/EY/NEI NIH HHS/United States
GR  - R01 EY011610/EY/NEI NIH HHS/United States
GR  - R01 EY019327/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Electroretinography
MH  - Female
MH  - Follow-Up Studies
MH  - Glaucoma/*pathology/physiopathology
MH  - Macaca mulatta
MH  - Macula Lutea/*pathology/*physiopathology
MH  - Male
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
PMC - PMC4849889
EDAT- 2016/04/16 06:00
MHDA- 2016/08/24 06:00
PMCR- 2016/10/01
CRDT- 2016/04/16 06:00
PHST- 2016/04/16 06:00 [entrez]
PHST- 2016/04/16 06:00 [pubmed]
PHST- 2016/08/24 06:00 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - 2515095 [pii]
AID - IOVS-15-18119 [pii]
AID - 10.1167/iovs.15-18119 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1892-900. doi: 10.1167/iovs.15-18119.