PMID- 27082611
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 15
DP  - 2016 Apr
TI  - Exclusive or Partial Breastfeeding for 6 Months Is Associated With Reduced Milk 
      Sensitization and Risk of Eczema in Early Childhood: The PATCH Birth Cohort 
      Study.
PG  - e3391
LID - 10.1097/MD.0000000000003391 [doi]
LID - e3391
AB  - There is insufficient evidence to confirm the association between breastfeeding 
      and allergic outcomes later in life. This study aimed to determine the 
      relationships between different breastfeeding patterns and allergen 
      sensitizations and risk of developing atopic diseases in early childhood. A total 
      of 186 children from a birth cohort in the Prediction of Allergies in Taiwanese 
      Children study for a 4-year follow-up period were enrolled. Total serum 
      immunoglobulin E (IgE) levels and specific IgE antibodies against food and 
      inhalant allergens were measured sequentially at 6 months as well as at 1, 1.5, 
      2, 3, and 4 years of age. A significantly lower prevalence of milk sensitization 
      was found in children at ages 1 and 1.5 years who were exclusively or partially 
      breastfed for >/=6 months. Breastfeeding >/=6 months was significantly associated 
      with a reduced risk of developing eczema but not allergic rhinitis and asthma at 
      ages 1 and 2 years. Compared with exclusive breastfeeding >/=6 months, partial 
      breastfeeding <6 months was significantly associated with an increased risk of 
      developing eczema at ages 1 and 2 years. As with exclusive breastfeeding, partial 
      breastfeeding for at least 6 months appears to be associated with a reduced 
      prevalence of milk sensitization as well as a reduced risk of developing eczema 
      in early childhood.
FAU - Chiu, Chih-Yung
AU  - Chiu CY
AD  - From the Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and 
      Chang Gung University College of Medicine (C-YC, S-LL, K-WS, M-HT, M-CH); and 
      Division of Pediatric Pulmonology (C-YC, S-HL) and Division of Allergy, Asthma, 
      and Rheumatology, Department of Pediatrics (L-CC, T-CY, K-WY, J-LH), Chang Gung 
      Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan, 
      Taiwan.
FAU - Liao, Sui-Ling
AU  - Liao SL
FAU - Su, Kuan-Wen
AU  - Su KW
FAU - Tsai, Ming-Han
AU  - Tsai MH
FAU - Hua, Man-Chin
AU  - Hua MC
FAU - Lai, Shen-Hao
AU  - Lai SH
FAU - Chen, Li-Chen
AU  - Chen LC
FAU - Yao, Tsung-Chieh
AU  - Yao TC
FAU - Yeh, Kuo-Wei
AU  - Yeh KW
FAU - Huang, Jing-Long
AU  - Huang JL
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/blood
MH  - Asthma/epidemiology
MH  - Breast Feeding/*statistics & numerical data
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Eczema/*epidemiology
MH  - Humans
MH  - Hypersensitivity/epidemiology
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Infant, Newborn
MH  - Milk Hypersensitivity/*epidemiology
MH  - Taiwan
MH  - Time Factors
PMC - PMC4839855
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/04/16 06:00
MHDA- 2016/09/13 06:00
PMCR- 2016/04/18
CRDT- 2016/04/16 06:00
PHST- 2016/04/16 06:00 [entrez]
PHST- 2016/04/16 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
PHST- 2016/04/18 00:00 [pmc-release]
AID - 00005792-201604120-00074 [pii]
AID - 10.1097/MD.0000000000003391 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Apr;95(15):e3391. doi: 10.1097/MD.0000000000003391.