PMID- 27083055
OWN - NLM
STAT- MEDLINE
DCOM- 20171120
LR  - 20181202
IS  - 1937-335X (Electronic)
IS  - 1937-3341 (Linking)
VI  - 22
IP  - 9-10
DP  - 2016 May
TI  - Controlled Release of Chemotherapeutic Platinum-Bisphosphonate Complexes from 
      Injectable Calcium Phosphate Cements.
PG  - 788-800
LID - 10.1089/ten.TEA.2016.0001 [doi]
AB  - Herein, we present a method to release chemotherapeutic platinum-bisphosphonate 
      (Pt-BP) complexes from apatitic calcium phosphate cements (CPCs). Pt-BP-loaded 
      hydroxyapatite nanoparticles (HA NPs) were added at different ratios to the 
      powder phase of the cements, which contained poly(D,L-lactic-co-glycolic acid) 
      (PLGA) microspheres as porogens to accelerate their degradation. In vitro release 
      kinetics of Pt-BP complexes revealed that the release rate of Pt species can be 
      tuned by varying the amount of drug-loaded HA NPs as well as modifying the 
      chemical structure of the Pt-BP complex to tailor its affinity with HA NPs. In 
      addition, the incorporation of PLGA microspheres into the CPCs increased the 
      degradation rate of the materials without affecting the release rate of Pt 
      species. Finally, the antiproliferative activity of the free Pt-BP complexes and 
      Pt-BP-loaded CPCs was evaluated using both human osteosarcoma cancer cells 
      (MG-63) and human bone marrow-derived mesenchymal stromal cells (h-BMMSCs). This 
      study demonstrated that both free Pt-BP complexes and the releasates from the 
      CPCs were antiproliferative in a dose-dependent manner. Moreover, their 
      antiproliferative activity was higher on MG-63 cells compared to h-BMMSC primary 
      cells. In summary, it was shown that injectable CPCs can be rendered 
      chemotherapeutically active by incorporation of HA NPs loaded with HA-binding 
      Pt-BP complexes.
FAU - Farbod, Kambiz
AU  - Farbod K
AD  - 1 Department of Biomaterials, Radboud Institute for Molecular Life Sciences, 
      Radboud University Medical Center , Nijmegen, The Netherlands .
FAU - Sariibrahimoglu, Kemal
AU  - Sariibrahimoglu K
AD  - 1 Department of Biomaterials, Radboud Institute for Molecular Life Sciences, 
      Radboud University Medical Center , Nijmegen, The Netherlands .
FAU - Curci, Alessandra
AU  - Curci A
AD  - 2 Department of Chemistry, Universita degli Studi di Bari Aldo Moro , Bari, Italy 
      .
FAU - Hayrapetyan, Astghik
AU  - Hayrapetyan A
AD  - 1 Department of Biomaterials, Radboud Institute for Molecular Life Sciences, 
      Radboud University Medical Center , Nijmegen, The Netherlands .
FAU - Hakvoort, Jan N W
AU  - Hakvoort JN
AD  - 1 Department of Biomaterials, Radboud Institute for Molecular Life Sciences, 
      Radboud University Medical Center , Nijmegen, The Netherlands .
FAU - van den Beucken, Jeroen J J P
AU  - van den Beucken JJ
AD  - 1 Department of Biomaterials, Radboud Institute for Molecular Life Sciences, 
      Radboud University Medical Center , Nijmegen, The Netherlands .
FAU - Iafisco, Michele
AU  - Iafisco M
AD  - 3 Institute of Science and Technology for Ceramics (ISTEC) , National Research 
      Council (CNR), Faenza, Italy .
FAU - Margiotta, Nicola
AU  - Margiotta N
AD  - 2 Department of Chemistry, Universita degli Studi di Bari Aldo Moro , Bari, Italy 
      .
FAU - Leeuwenburgh, Sander C G
AU  - Leeuwenburgh SC
AD  - 1 Department of Biomaterials, Radboud Institute for Molecular Life Sciences, 
      Radboud University Medical Center , Nijmegen, The Netherlands .
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tissue Eng Part A
JT  - Tissue engineering. Part A
JID - 101466659
RN  - 0 (Bone Cements)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Diphosphonates)
RN  - 49DFR088MY (Platinum)
RN  - 91D9GV0Z28 (Durapatite)
SB  - IM
MH  - *Bone Cements/chemistry/pharmacokinetics/pharmacology
MH  - Bone Marrow Cells/cytology/*metabolism
MH  - Cell Line, Tumor
MH  - Delayed-Action Preparations/chemistry/pharmacology
MH  - *Diphosphonates/chemistry/pharmacokinetics/pharmacology
MH  - *Durapatite/chemistry/pharmacokinetics/pharmacology
MH  - Humans
MH  - Mesenchymal Stem Cells/cytology/*metabolism
MH  - Nanoparticles/*chemistry
MH  - *Platinum/chemistry/pharmacokinetics/pharmacology
EDAT- 2016/04/17 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/04/17 06:00
PHST- 2016/04/17 06:00 [entrez]
PHST- 2016/04/17 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 10.1089/ten.TEA.2016.0001 [doi]
PST - ppublish
SO  - Tissue Eng Part A. 2016 May;22(9-10):788-800. doi: 10.1089/ten.TEA.2016.0001.