PMID- 27083941
OWN - NLM
STAT- MEDLINE
DCOM- 20160905
LR  - 20160416
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 202
IP  - 1
DP  - 2016 May 1
TI  - Enhanced tumor growth in the remaining lung after major lung resection.
PG  - 1-7
LID - S0022-4804(15)01184-1 [pii]
LID - 10.1016/j.jss.2015.12.012 [doi]
AB  - BACKGROUND: Pneumonectomy induces active growth of the remaining lung in order to 
      compensate for lost lung tissue. We hypothesized that tumor progression is 
      enhanced in the activated local environment. METHODS: We examined the effects of 
      mechanical strain on the activation of lung growth and tumor progression in mice. 
      The mechanical strain imposed on the right lung after left pneumonectomy was 
      neutralized by filling the empty space that remained after pneumonectomy with a 
      polypropylene prosthesis. RESULTS: The neutralization of the strain prevented 
      active lung growth. According to an angiogenesis array, stronger monocyte 
      chemoattractant protein-1 (MCP-1) expression was found in the strain-induced 
      growing lung. The neutralization of the strain attenuated the release of MCP-1 
      from the lung cells. The intravenous injection of Lewis lung cancer cells 
      resulted in the enhanced development of metastatic foci in the strain-induced 
      growing lung, but the enhanced development was canceled by the neutralization of 
      the strain. An immunohistochemical analysis revealed the prominent accumulation 
      of tumor-associated macrophages in tumors arising in the strain-induced growing 
      lung, and that there was a relationship between the accumulation and the MCP-1 
      expression status. CONCLUSIONS: Our results suggested that mechanical lung 
      strain, induced by pulmonary resection, triggers active lung growth, thereby 
      creating a tumor-friendly environment. The modification of that environment, as 
      well as the minimizing of surgical stress, may be a meaningful strategy to 
      improve the therapeutic outcome after lung cancer surgery.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Sano, Fumiho
AU  - Sano F
AD  - Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi 
      University Graduate School of Medicine, Ube, Yamaguchi, Japan.
FAU - Ueda, Kazuhiro
AU  - Ueda K
AD  - Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi 
      University Graduate School of Medicine, Ube, Yamaguchi, Japan. Electronic 
      address: kaueda@c-able.ne.jp.
FAU - Murakami, Junichi
AU  - Murakami J
AD  - Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi 
      University Graduate School of Medicine, Ube, Yamaguchi, Japan.
FAU - Hayashi, Masataro
AU  - Hayashi M
AD  - Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi 
      University Graduate School of Medicine, Ube, Yamaguchi, Japan.
FAU - Nishimoto, Arata
AU  - Nishimoto A
AD  - Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi 
      University Graduate School of Medicine, Ube, Yamaguchi, Japan.
FAU - Hamano, Kimikazu
AU  - Hamano K
AD  - Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi 
      University Graduate School of Medicine, Ube, Yamaguchi, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151217
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Lewis Lung/metabolism/pathology/*surgery
MH  - Chemokine CCL2/metabolism
MH  - Lung/growth & development/metabolism/*pathology/surgery
MH  - Lung Neoplasms/metabolism/pathology/*surgery
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pneumonectomy/*adverse effects/methods
MH  - Prostheses and Implants
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Compensatory lung growth
OT  - Lung cancer
OT  - Microenvironment
OT  - Monocyte chemoattractant protein-1
OT  - Pulmonary resection
EDAT- 2016/04/17 06:00
MHDA- 2016/09/07 06:00
CRDT- 2016/04/17 06:00
PHST- 2015/09/23 00:00 [received]
PHST- 2015/11/27 00:00 [revised]
PHST- 2015/12/11 00:00 [accepted]
PHST- 2016/04/17 06:00 [entrez]
PHST- 2016/04/17 06:00 [pubmed]
PHST- 2016/09/07 06:00 [medline]
AID - S0022-4804(15)01184-1 [pii]
AID - 10.1016/j.jss.2015.12.012 [doi]
PST - ppublish
SO  - J Surg Res. 2016 May 1;202(1):1-7. doi: 10.1016/j.jss.2015.12.012. Epub 2015 Dec 
      17.