PMID- 27084561
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20220316
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 123
IP  - 8
DP  - 2016 Aug
TI  - Description and Prevalence of Spondyloarthritis in Patients with Anterior 
      Uveitis: The SENTINEL Interdisciplinary Collaborative Project.
PG  - 1632-1636
LID - S0161-6420(16)00347-X [pii]
LID - 10.1016/j.ophtha.2016.03.010 [doi]
AB  - PURPOSE: To describe and analyze the prevalence of spondyloarthritis (SpA) in 
      patients with anterior uveitis (AU). DESIGN: Multicentric, observational, 
      prospective study. PARTICIPANTS: Consecutive patients with AU who were human 
      leukocyte antigen (HLA)-B27 positive or HLA-B27 negative with more than 1 episode 
      of AU separated by at least 3 months were selected. Patients with a previous 
      diagnosis of SpA were excluded. METHODS: Included patients were evaluated by an 
      ophthalmologist and a rheumatologist following a predefined visit schedule. MAIN 
      OUTCOME MEASURES: Sociodemographic and clinical variables including the diagnosis 
      of SpA according to Assessment of SpondyloArthritis International Society (ASAS) 
      criteria and an exhaustive ophthalmological examination (best-corrected visual 
      acuity, intraocular pressure, biomicroscopic examination of the anterior and 
      posterior segment of the eye, cataract evaluation, optical coherence tomography 
      evaluating both the 1-mm central retina thickness and the optic nerve head and 
      retinal nerve fiber layer, and visual field in a dark room with 1 eye patched) 
      were collected. Baseline descriptive, bivariate, and concordance analyses were 
      performed. RESULTS: We included 798 patients, mostly men (59%) with a mean age of 
      45 years; 60% were AU HLA-B27 positive, and 40% had recurrent negative AU 
      HLA-B27. A total of 50.2% and 17.5% of patients presented axial and peripheral 
      SpA according to ASAS criteria, respectively. Patients with AU who were HLA-B27 
      positive were more frequently diagnosed with axial (69.8% vs. 27.3%, P < 0.0001) 
      and peripheral SpA (21.9% vs. 11.1%, P < 0.0001) than patients with recurrent 
      negative AU HLA-B27. In general, we did not detect important differences between 
      groups in the ophthalmologic variables. CONCLUSIONS: A large percentage of 
      patients with clinically significant AU have an undiagnosed SpA. This percentage 
      is even higher if the HLA-B27 haplotype is positive.
CI  - Copyright (c) 2016 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Juanola, Xavier
AU  - Juanola X
AD  - Rheumatology Unit, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, 
      Barcelona, Spain.
FAU - Loza Santamaria, Estibaliz
AU  - Loza Santamaria E
AD  - Instituto de Salud Musculoesqueletica, Madrid, Spain. Electronic address: 
      estibaliz.loza@inmusc.eu.
FAU - Cordero-Coma, Miguel
AU  - Cordero-Coma M
AD  - Uveitis Unit, University Hospital of Leon, Leon, Spain; Instituto de Biomedicina 
      (IBIOMED), University of Leon, Spain.
CN  - SENTINEL Working Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20160412
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 0 (HLA-B27 Antigen)
SB  - IM
CIN - Ophthalmology. 2016 Aug;123(8):1630-1631. PMID: 27450813
MH  - Adult
MH  - Female
MH  - HLA-B27 Antigen/immunology
MH  - Humans
MH  - Interdisciplinary Studies
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Prevalence
MH  - Prospective Studies
MH  - Retina/pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Spain/epidemiology
MH  - Spondylarthritis/diagnosis/*epidemiology/immunology
MH  - Tomography, Optical Coherence
MH  - Uveitis, Anterior/diagnosis/*epidemiology/immunology
MH  - Visual Acuity/physiology
MH  - Visual Fields/physiology
EDAT- 2016/04/17 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/04/17 06:00
PHST- 2016/01/07 00:00 [received]
PHST- 2016/03/02 00:00 [revised]
PHST- 2016/03/07 00:00 [accepted]
PHST- 2016/04/17 06:00 [entrez]
PHST- 2016/04/17 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
AID - S0161-6420(16)00347-X [pii]
AID - 10.1016/j.ophtha.2016.03.010 [doi]
PST - ppublish
SO  - Ophthalmology. 2016 Aug;123(8):1632-1636. doi: 10.1016/j.ophtha.2016.03.010. Epub 
      2016 Apr 12.