PMID- 27085135
OWN - NLM
STAT- MEDLINE
DCOM- 20170411
LR  - 20170411
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 125
DP  - 2016 Jun 5
TI  - Preparation of magnetic ODS-PAN thin-films for microextraction of quetiapine and 
      clozapine in plasma and urine samples followed by HPLC-UV detection.
PG  - 319-28
LID - S0731-7085(16)30192-3 [pii]
LID - 10.1016/j.jpba.2016.04.006 [doi]
AB  - In this study, conventional thin-film microextraction (TFME) was endowed with 
      magnetic by introducing superparamagnetic SiO2@Fe3O4 nanoparticles in thin-films. 
      Novel magnetic octadecylsilane (ODS)-polyacrylonitrile (PAN) thin-films were 
      prepared by spraying, and used for the microextraction of quetiapine and 
      clozapine in plasma and urine samples, followed by the detection of HPLC-UV. The 
      influencing factors on the extraction efficiency of magnetic ODS-PAN TFME, 
      including pH, extraction time, desorption solvent, desorption time, and ion 
      strength were investigated systematically. Under the optimal conditions, both 
      analytes showed good linearity over ranges of 0.070-9.000mugmL(-1) and 
      0.012-9.000mugmL(-1) in plasma and urine samples, respectively, with correlation 
      coefficients (R(2)) above 0.9990. Limits of detection (LODs) for quetiapine in 
      plasma and urine samples were 0.013 and 0.003mugmL(-1), respectively. LODs for 
      clozapine in plasma and urine samples were 0.015 and 0.003mugmL(-1), respectively. 
      The relative standard deviations (RSDs) for quetiapine and clozapine were less 
      than 9.23%. After the validation, the protocol was successfully applied for the 
      determination of quetiapine and clozapine in patients' plasma and urine samples 
      with satisfactory recoveries between 99-110%. The proposed magnetic ODS-PAN TFME 
      was very simple, fast and easy to handle. It showed high potential as a powerful 
      pretreatment technology for routine therapeutic drug monitoring (TDM) in plasma 
      and urine samples.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Li, Dan
AU  - Li D
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Tongji Medical 
      College, Huazhong University of Science and Technology, PR China.
FAU - Zou, Juan
AU  - Zou J
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Tongji Medical 
      College, Huazhong University of Science and Technology, PR China.
FAU - Cai, Pei-Shan
AU  - Cai PS
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Tongji Medical 
      College, Huazhong University of Science and Technology, PR China.
FAU - Xiong, Chao-Mei
AU  - Xiong CM
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Tongji Medical 
      College, Huazhong University of Science and Technology, PR China. Electronic 
      address: cmxiong2002@hust.edu.cn.
FAU - Ruan, Jin-Lan
AU  - Ruan JL
AD  - Department of Pharmaceutical Analysis, School of Pharmacy, Tongji Medical 
      College, Huazhong University of Science and Technology, PR China.
LA  - eng
PT  - Journal Article
DEP - 20160406
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 2S3PL1B6UJ (Quetiapine Fumarate)
RN  - J60AR2IKIC (Clozapine)
SB  - IM
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Clozapine/*blood/*urine
MH  - Humans
MH  - Limit of Detection
MH  - *Magnetics
MH  - Microscopy, Electron, Scanning
MH  - Quetiapine Fumarate/*blood/*urine
MH  - Spectrophotometry, Ultraviolet/*methods
OTO - NOTNLM
OT  - Clozapine
OT  - HPLC-UV
OT  - Magnetic octadecylsilane-polyacrylonitrile thin-film microextraction (ODS-PAN 
      TFME)
OT  - Plasma
OT  - Quetiapine
OT  - Therapeutic drug monitoring (TDM)
OT  - Urine
EDAT- 2016/04/17 06:00
MHDA- 2017/04/12 06:00
CRDT- 2016/04/17 06:00
PHST- 2015/08/24 00:00 [received]
PHST- 2016/04/05 00:00 [revised]
PHST- 2016/04/05 00:00 [accepted]
PHST- 2016/04/17 06:00 [entrez]
PHST- 2016/04/17 06:00 [pubmed]
PHST- 2017/04/12 06:00 [medline]
AID - S0731-7085(16)30192-3 [pii]
AID - 10.1016/j.jpba.2016.04.006 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2016 Jun 5;125:319-28. doi: 10.1016/j.jpba.2016.04.006. Epub 
      2016 Apr 6.