PMID- 27085769
OWN - NLM
STAT- MEDLINE
DCOM- 20160826
LR  - 20190927
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 65
IP  - 5
DP  - 2016 May
TI  - Targeting specific interstitial glycemic parameters with high-intensity interval 
      exercise and fasted-state exercise in type 2 diabetes.
PG  - 599-608
LID - S0026-0495(16)00006-8 [pii]
LID - 10.1016/j.metabol.2016.01.003 [doi]
AB  - AIMS: To compare the acute glycemic responses to a bout of high-intensity 
      interval exercise (HIIE) and energy-matched moderate-intensity continuous 
      exercise (MICE) performed under fasted and postprandial conditions. METHODS: A 
      randomized, controlled, crossover design was used. Ten individuals with type 2 
      diabetes were each tested in five experimental conditions after an overnight 
      fast: 1) fasted-state HIIE (HIIEfast); 2) post-breakfast HIIE (HIIEfed); 3) 
      fasted-state MICE (MICEfast); 4) post-breakfast MICE (MICEfed); and 5) no 
      exercise (control). MICE was performed at workload corresponding to 55% of 
      V.V̇O2peak, whereas HIIE was composed of repetitions of three minutes at workload 
      corresponding to 40% followed by one minute at workload corresponding to 100% 
      V.V̇̇O2peak. Interstitial glucose was monitored by continuous glucose monitoring 
      over 24h under standardized diet and medication. RESULTS: Fasted-state exercise 
      attenuated postprandial glycemic increments (p<0.05) to a greater extent than 
      post-breakfast exercise did. HIIE reduced nocturnal and fasting glycemia on the 
      day following exercise more than MICE did (main effect: both p<0.05). Compared to 
      the control condition, HIIEfast lowered most interstitial glycemic parameters, 
      i.e., 24-h mean glucose (-1.5mmol.l(-1); p<0.05), fasting glucose 
      (-1.0mmol.l(-1); p<0.05), overall postprandial glycemic increment 
      (-257mmol.360min.l(-1); p<0.05), glycemic variability (-1.79mmol.l(-1); p<0.05), 
      and time spent in hyperglycemia (-283min; p<0.05). CONCLUSION: This study showed 
      that HIIE is more effective than MICE in lowering nocturnal/fasting glycemia. 
      Exercise performed in the fasted state reduces postprandial glycemic increments 
      to a greater extent than post-breakfast exercise does. Performing HIIE under 
      fasted condition may be most advantageous as it lowered most aspects of glycemia.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Terada, Tasuku
AU  - Terada T
AD  - Faculty of Physical Education & Recreation, University of Alberta, 1-052 Li Ka 
      Shing Center for Health Research Innovation, Physical Activity and Diabetes 
      Laboratory, Edmonton, Alberta, Canada, T6G 2H9.
FAU - Wilson, Ben J
AU  - Wilson BJ
AD  - Department of Medicine, Faculty of Medicine, University of Calgary, Foothills 
      Medical Center-North Tower, 9th Floor 1403-29th Street NW, Calgary, Alberta, 
      Canada, T2N 2T9.
FAU - Myette-Cote, Etienne
AU  - Myette-Cote E
AD  - Faculty of Physical Education & Recreation, University of Alberta, 1-052 Li Ka 
      Shing Center for Health Research Innovation, Physical Activity and Diabetes 
      Laboratory, Edmonton, Alberta, Canada, T6G 2H9.
FAU - Kuzik, Nicholas
AU  - Kuzik N
AD  - Faculty of Physical Education & Recreation, University of Alberta, 1-052 Li Ka 
      Shing Center for Health Research Innovation, Physical Activity and Diabetes 
      Laboratory, Edmonton, Alberta, Canada, T6G 2H9.
FAU - Bell, Gordon J
AU  - Bell GJ
AD  - Faculty of Physical Education & Recreation, University of Alberta, 1-052 Li Ka 
      Shing Center for Health Research Innovation, Physical Activity and Diabetes 
      Laboratory, Edmonton, Alberta, Canada, T6G 2H9.
FAU - McCargar, Linda J
AU  - McCargar LJ
AD  - Department of Agricultural, Food and Nutritional Science, University of Alberta, 
      2-012D Li Ka Shing Center for Health Research Innovation, Edmonton, Alberta, 
      Canada, T6G 2H9.
FAU - Boule, Normand G
AU  - Boule NG
AD  - Faculty of Physical Education & Recreation, University of Alberta, 1-052 Li Ka 
      Shing Center for Health Research Innovation, Physical Activity and Diabetes 
      Laboratory, Edmonton, Alberta, Canada, T6G 2H9. Electronic address: 
      nboule@ualberta.ca.
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20160111
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Alberta
MH  - Breakfast
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 2/metabolism/*therapy
MH  - Energy Metabolism
MH  - Extracellular Fluid/metabolism
MH  - Fasting
MH  - Female
MH  - Glucose/metabolism
MH  - Humans
MH  - Hyperglycemia/etiology/*prevention & control
MH  - Hypoglycemia/etiology/*prevention & control
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Ambulatory
MH  - *Motor Activity
MH  - Oxygen Consumption
MH  - *Physical Exertion
MH  - Postprandial Period
OTO - NOTNLM
OT  - Continuous glucose monitoring
OT  - Fasted-state exercise
OT  - Glycemic variability
OT  - High-intensity interval exercise
OT  - Postprandial glucose concentration
EDAT- 2016/04/18 06:00
MHDA- 2016/08/27 06:00
CRDT- 2016/04/18 06:00
PHST- 2015/08/25 00:00 [received]
PHST- 2015/12/30 00:00 [revised]
PHST- 2016/01/06 00:00 [accepted]
PHST- 2016/04/18 06:00 [entrez]
PHST- 2016/04/18 06:00 [pubmed]
PHST- 2016/08/27 06:00 [medline]
AID - S0026-0495(16)00006-8 [pii]
AID - 10.1016/j.metabol.2016.01.003 [doi]
PST - ppublish
SO  - Metabolism. 2016 May;65(5):599-608. doi: 10.1016/j.metabol.2016.01.003. Epub 2016 
      Jan 11.