PMID- 27086080
OWN - NLM
STAT- MEDLINE
DCOM- 20170116
LR  - 20170116
IS  - 1638-6183 (Electronic)
IS  - 0300-9084 (Linking)
VI  - 126
DP  - 2016 Jul
TI  - One carbon metabolism and bone homeostasis and remodeling: A review of 
      experimental research and population studies.
PG  - 115-23
LID - S0300-9084(16)30052-9 [pii]
LID - 10.1016/j.biochi.2016.04.009 [doi]
AB  - Homocysteine (HCY) is a degradation product of the methionine pathway. The B 
      vitamins, in particular vitamin B12 and folate, are the primary nutritional 
      determinant of HCY levels and therefore their deficiencies result in 
      hyperhomocysteinaemia (HHCY). Prevalence of hyperhomocysteinemia (HHCY) and 
      related dietary deficiencies in B vitamins and folate increase with age and have 
      been related to osteoporosis and abnormal development of epiphyseal cartilage and 
      bone in rodents. Here we provide a review of experimental and population studies. 
      The negative effects of HHCY and/or B vitamins and folate deficiencies on bone 
      formation and remodeling are documented by cell models, including primary 
      osteoblasts, osteoclast and bone progenitor cells as well as by animal and human 
      studies. However, underlying pathophysiological mechanisms are complex and remain 
      poorly understood. Whether these associations are the direct consequences of 
      impaired one carbon metabolism is not clarified and more studies are still needed 
      to translate these findings to human population. To date, the evidence is limited 
      and somewhat conflicting, however further trials in groups most vulnerable to 
      impaired one carbon metabolism are required.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Feigerlova, Eva
AU  - Feigerlova E
AD  - INSERM U954, Nutrition Genetique et Exposition aux Risques Environnementaux, 
      Medical Faculty, University of Lorraine and Regional University Hospital Center 
      of Nancy, Vandoeuvre les Nancy, France. Electronic address: 
      eva.feigerlova@fulbrightmail.org.
FAU - Demarquet, Lea
AU  - Demarquet L
AD  - INSERM U954, Nutrition Genetique et Exposition aux Risques Environnementaux, 
      Medical Faculty, University of Lorraine and Regional University Hospital Center 
      of Nancy, Vandoeuvre les Nancy, France; Division of Endocrinology, Regional 
      University Hospital Center of Nancy, Vandoeuvre les Nancy, France.
FAU - Gueant, Jean-Louis
AU  - Gueant JL
AD  - INSERM U954, Nutrition Genetique et Exposition aux Risques Environnementaux, 
      Medical Faculty, University of Lorraine and Regional University Hospital Center 
      of Nancy, Vandoeuvre les Nancy, France. Electronic address: 
      jean-louis.gueant@univ-lorraine.fr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160413
PL  - France
TA  - Biochimie
JT  - Biochimie
JID - 1264604
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 7440-44-0 (Carbon)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Animals
MH  - *Bone Remodeling
MH  - Bone and Bones/*metabolism/pathology
MH  - Carbon/*metabolism
MH  - Folic Acid/*metabolism
MH  - *Homeostasis
MH  - Homocysteine/metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/metabolism/pathology
MH  - Osteoblasts/*metabolism/pathology
MH  - Osteoclasts/*metabolism
MH  - Vitamin B 12/*metabolism
MH  - Vitamin B Deficiency/metabolism/pathology
OTO - NOTNLM
OT  - Bone
OT  - Folate
OT  - Homocysteine
OT  - One carbon metabolism
OT  - Vitamin B12
EDAT- 2016/04/18 06:00
MHDA- 2017/01/17 06:00
CRDT- 2016/04/18 06:00
PHST- 2015/12/02 00:00 [received]
PHST- 2016/04/08 00:00 [accepted]
PHST- 2016/04/18 06:00 [entrez]
PHST- 2016/04/18 06:00 [pubmed]
PHST- 2017/01/17 06:00 [medline]
AID - S0300-9084(16)30052-9 [pii]
AID - 10.1016/j.biochi.2016.04.009 [doi]
PST - ppublish
SO  - Biochimie. 2016 Jul;126:115-23. doi: 10.1016/j.biochi.2016.04.009. Epub 2016 Apr 
      13.