PMID- 27086249
OWN - NLM
STAT- MEDLINE
DCOM- 20170102
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 238
DP  - 2016 Apr 30
TI  - Obtaining employment as an anchor for estimating the minimum clinically important 
      difference on the Positive and Negative Syndrome Scale (PANSS) in schizophrenia.
PG  - 304-309
LID - S0165-1781(16)30259-1 [pii]
LID - 10.1016/j.psychres.2016.02.018 [doi]
AB  - Statistical differences on clinical scales are often used to compare the 
      effectiveness of treatments. However, statistical significance does not 
      necessarily indicate clinical significance. The minimum clinically important 
      difference (MCID) refers to clinically meaningful treatment differences. This 
      study estimates the MCID of the Positive and Negative Syndrome Scale (PANSS) by 
      anchoring the change in scores to an objective clinical outcome: employment. This 
      secondary analysis compared PANSS score change from baseline among 1049 
      non-working individuals with schizophrenia, who were followed and categorized as 
      either having not worked, worked 1-10 days, or worked >10 days at 15 or 18 
      months. The difference in change in average PANSS Total scores between 
      participants who did not work and those who worked 1-10 days (4.25 points) and 
      >10 days (8.30) were statistically significant. This study estimates the MCID for 
      the PANSS to be between 4.25 and 8.30 Total points. This study revealed 
      significant differences in PANSS score changes between participants who did and 
      did not work. Using employment, an objective and clinically meaningful change in 
      health status, to determine the MCID of PANSS resulted in estimates lower than 
      previously reported. MCID estimates vary across methods but using objective 
      anchors increases face validity.
CI  - Published by Elsevier Ireland Ltd.
FAU - Leddy-Stacy, Meaghan A
AU  - Leddy-Stacy MA
AD  - Department of Psychology, Veterans Affairs Connecticut Health Care System, 950 
      Campbell Avenue, 116B, West Haven, CT 06510, USA; Department of Psychiatry, Yale 
      University School of Medicine, 300 George St., Suite 901, New Haven, CT 06511, 
      USA. Electronic address: meaghan.leddy@yale.edu.
FAU - Rosenheck, Robert
AU  - Rosenheck R
AD  - Department of Psychiatry, Yale University School of Medicine, 300 George St., 
      Suite 901, New Haven, CT 06511, USA; Veterans Affairs New England Mental Illness 
      Research, Education and Clinical Centers (MIRECC), 950 Campbell Avenue, West 
      Haven, CT 06510, USA.
LA  - eng
PT  - Journal Article
DEP - 20160213
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - *Employment, Supported
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Rehabilitation, Vocational
MH  - Reproducibility of Results
MH  - Schizophrenia/complications/diagnosis/*drug therapy/*rehabilitation
MH  - *Schizophrenic Psychology
MH  - Self Concept
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Clinical trials as topic
OT  - Employment
OT  - Psychiatric status rating scales
OT  - Research design
OT  - Schizophrenia
OT  - Treatment outcome
EDAT- 2016/04/18 06:00
MHDA- 2017/01/04 06:00
CRDT- 2016/04/18 06:00
PHST- 2015/04/03 00:00 [received]
PHST- 2015/10/16 00:00 [revised]
PHST- 2016/02/12 00:00 [accepted]
PHST- 2016/04/18 06:00 [entrez]
PHST- 2016/04/18 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
AID - S0165-1781(16)30259-1 [pii]
AID - 10.1016/j.psychres.2016.02.018 [doi]
PST - ppublish
SO  - Psychiatry Res. 2016 Apr 30;238:304-309. doi: 10.1016/j.psychres.2016.02.018. 
      Epub 2016 Feb 13.