PMID- 27086968
OWN - NLM
STAT- MEDLINE
DCOM- 20170628
LR  - 20171204
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1642
DP  - 2016 Jul 1
TI  - Altered monoamine system activities after prenatal and adult stress: A role for 
      stress resilience?
PG  - 409-418
LID - S0006-8993(16)30249-9 [pii]
LID - 10.1016/j.brainres.2016.04.032 [doi]
AB  - INTRODUCTION: Prenatal stress (PNS) and stress in adulthood are risk factors for 
      development of major depressive disorder. The present study aimed to 1) confirm 
      previous neuroendocrine and behavioral changes induced by PNS, and 2) to 
      characterize the effect of early- and late life stress on the in vivo activity of 
      monoamine systems. METHODS: Gestational dams were restrained thrice daily under 
      bright illumination from gestational day (GD)11-20. Behavior and neuroendocrine 
      responses to the forced swim test (FST) were determined in adult (50-80 days) 
      offspring, and electrophysiological single unit recordings of dorsal raphe 
      nucleus serotonin (5-HT), ventral tegmental area dopamine (DA) and locus 
      coeruleus norepinephrine (NE) neurons were obtained at baseline and 24h after the 
      FST. RESULTS: Gestational dams did not habituate to chronic restraint stress, and 
      PNS reduced the birth weight of offspring. In adulthood, swim stress elevated 
      CORT levels longer in PNS animals, while it had no effect on swim behaviors. 
      Baseline firing activity of 5-HT neurons was decreased in PNS animals, while the 
      firing activity of NE and DA neurons was increased. Swim stress had no effect on 
      the firing on 5-HT neurons, but normalized the firing activity of catecholamine 
      neurons in PNS animals. CONCLUSION: The present data confirm previously 
      established effects on neuroendocrine and physiological measures, and demonstrate 
      an altering effect of PNS and stress on monoamine system activities in adulthood. 
      Since PNS did not result in a depressive-like phenotype, these central changes 
      following PNS might play reflect adaptive changes contributing to stress 
      resilience in adulthood.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Oosterhof, Chris A
AU  - Oosterhof CA
AD  - University of Ottawa, Institute of Mental Health Research, Ontario, Canada; 
      Department of Cellular and Molecular medicine, University of Ottawa, Ontario, 
      Canada. Electronic address: Chris.Oosterhof@TheRoyal.ca.
FAU - El Mansari, Mostafa
AU  - El Mansari M
AD  - University of Ottawa, Institute of Mental Health Research, Ontario, Canada.
FAU - Merali, Zul
AU  - Merali Z
AD  - University of Ottawa, Institute of Mental Health Research, Ontario, Canada; 
      Department of Cellular and Molecular medicine, University of Ottawa, Ontario, 
      Canada.
FAU - Blier, Pierre
AU  - Blier P
AD  - University of Ottawa, Institute of Mental Health Research, Ontario, Canada; 
      Department of Cellular and Molecular medicine, University of Ottawa, Ontario, 
      Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160414
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 333DO1RDJY (Serotonin)
RN  - VTD58H1Z2X (Dopamine)
RN  - W980KJ009P (Corticosterone)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Action Potentials/physiology
MH  - Animals
MH  - Corticosterone/blood
MH  - Disease Models, Animal
MH  - Dopamine/*metabolism
MH  - Female
MH  - Male
MH  - Mesencephalon/growth & development/metabolism
MH  - Microelectrodes
MH  - Neurons/metabolism
MH  - Norepinephrine/*metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1A/metabolism
MH  - *Resilience, Psychological
MH  - Serotonin/*metabolism
MH  - Stress, Psychological/*metabolism
OTO - NOTNLM
OT  - Depressive-like behavior
OT  - Dopamine
OT  - Norepinephrine
OT  - Prenatal stress
OT  - Serotonin
OT  - Single unit electrophysiological recordings
EDAT- 2016/04/19 06:00
MHDA- 2017/06/29 06:00
CRDT- 2016/04/19 06:00
PHST- 2015/10/01 00:00 [received]
PHST- 2016/04/12 00:00 [revised]
PHST- 2016/04/13 00:00 [accepted]
PHST- 2016/04/19 06:00 [entrez]
PHST- 2016/04/19 06:00 [pubmed]
PHST- 2017/06/29 06:00 [medline]
AID - S0006-8993(16)30249-9 [pii]
AID - 10.1016/j.brainres.2016.04.032 [doi]
PST - ppublish
SO  - Brain Res. 2016 Jul 1;1642:409-418. doi: 10.1016/j.brainres.2016.04.032. Epub 
      2016 Apr 14.