PMID- 27087278
OWN - NLM
STAT- MEDLINE
DCOM- 20171121
LR  - 20211204
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 71
IP  - 7
DP  - 2016 Jul
TI  - Childhood atopic dermatitis-Brain-derived neurotrophic factor correlates with 
      serum eosinophil cationic protein and disease severity.
PG  - 1062-5
LID - 10.1111/all.12916 [doi]
AB  - Several studies have shown that neurotrophins including brain-derived 
      neurotrophic factor (BDNF) play a role in chronic inflammatory skin diseases such 
      as atopic dermatitis (AD). BDNF is increased in the serum samples of adults with 
      AD. Interestingly, eosinophils of these patients can release and produce BDNF. We 
      analyzed BDNF serum levels with ELISA and their correlation with SCORAD score, 
      eosinophil cationic protein (ECP), total IgE, IL-4, IL-13 and IL-31 in children 
      with AD (n = 56) compared to nonatopic healthy children (n = 25). In addition, we 
      analyzed FLG loss-of-function mutations in 17 children with AD and their 
      connection to BDNF. BDNF serum levels were significantly higher in children with 
      AD. Further, BDNF correlated with disease activity, serum ECP, and total IgE 
      serum levels in AD. There was no difference in BDNF levels of filaggrin-positive 
      or filaggrin-negative children with AD, and there was no correlation of BDNF with 
      IL-31 and Th2 cytokines including IL-4 and IL-13. Together, our data add new 
      insights into the pathophysiology of AD, suggesting that serum BDNF which 
      correlates with disease severity contributes to the regulation of inflammation in 
      an eosinophil-, but not Th2-dependent manner.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Folster-Holst, R
AU  - Folster-Holst R
AD  - Department of Dermatology, Venerology and Allergy, University of Kiel, Kiel, 
      Germany.
FAU - Papakonstantinou, E
AU  - Papakonstantinou E
AD  - Department of Dermatology and Allergy, Hannover Medical School, Hannover, 
      Germany.
FAU - Rudrich, U
AU  - Rudrich U
AD  - Department of Dermatology and Allergy, Hannover Medical School, Hannover, 
      Germany.
FAU - Buchner, M
AU  - Buchner M
AD  - Department of Dermatology, Venerology and Allergy, University of Kiel, Kiel, 
      Germany.
FAU - Pite, H
AU  - Pite H
AD  - Allergy Center, CUF Descobertas Hospital and CUF Infante Santo Hospital, Lisbon, 
      Portugal.
FAU - Gehring, M
AU  - Gehring M
AD  - Department of Dermatology and Allergy, Hannover Medical School, Hannover, 
      Germany.
FAU - Kapp, A
AU  - Kapp A
AD  - Department of Dermatology and Allergy, Hannover Medical School, Hannover, 
      Germany.
FAU - Weidinger, S
AU  - Weidinger S
AD  - Department of Dermatology, Venerology and Allergy, University of Kiel, Kiel, 
      Germany.
FAU - Raap, U
AU  - Raap U
AD  - Department of Dermatology and Allergy, Hannover Medical School, Hannover, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20160506
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (FLG protein, human)
RN  - 0 (Filaggrin Proteins)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Biomarkers
MH  - Brain-Derived Neurotrophic Factor/blood/*metabolism
MH  - Child, Preschool
MH  - Cytokines/blood/metabolism
MH  - Dermatitis, Atopic/blood/*diagnosis/immunology/*metabolism
MH  - Eosinophil Cationic Protein/*blood
MH  - Eosinophils/immunology/metabolism
MH  - Female
MH  - Filaggrin Proteins
MH  - Humans
MH  - Infant
MH  - Male
MH  - Severity of Illness Index
MH  - Th2 Cells/immunology/metabolism
OTO - NOTNLM
OT  - atopic dermatitis
OT  - brain-derived neurotrophic factor
OT  - eczema
OT  - eosinophils
EDAT- 2016/04/19 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/04/19 06:00
PHST- 2016/04/12 00:00 [accepted]
PHST- 2016/04/19 06:00 [entrez]
PHST- 2016/04/19 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 10.1111/all.12916 [doi]
PST - ppublish
SO  - Allergy. 2016 Jul;71(7):1062-5. doi: 10.1111/all.12916. Epub 2016 May 6.