PMID- 27087431
OWN - NLM
STAT- MEDLINE
DCOM- 20170418
LR  - 20181113
IS  - 1308-5735 (Electronic)
IS  - 1308-5727 (Print)
VI  - 8
IP  - 3
DP  - 2016 Sep 1
TI  - Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction 
      by Leptin Levels in Newborns.
PG  - 321-4
LID - 10.4274/jcrpe.2693 [doi]
AB  - OBJECTIVE: Most adipose tissue programming is realized in early life. Also, the 
      postnatal three months, rather than the later phases of infancy, may be more 
      relevant in the development of an adverse cardiometabolic risk profile. The 
      adipokines phenotype, as a predictor of early-life weight gain, has been recently 
      explored in cord blood. To determine whether in addition to leptin levels in cord 
      samples, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 
      (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis 
      factor alpha (TNF-alpha) levels improve weight gain prediction during the first three 
      months of life. METHODS: Adiponectin, IL-6, MCP-1, leptin, resistin, PAI-1, and 
      TNF-alpha were measured by multiplex immunoassay in a subsample of 86 healthy term 
      newborns. RESULTS: Leptin levels significantly predicted weight gain at 3 months 
      of follow-up (r2=0.09, p=0.006). In the multivariate analysis, including 
      additional adipokines in the model, stepwise or all at once, did not increase the 
      prediction of weight gain after the first three months of life. CONCLUSION: 
      Adding adiponectin, IL-6, MCP-1, resistin, PAI-1, and TNF-alpha to the prediction 
      model of weight gain in healthy newborns did not prove to be useful. It is 
      probable that their relative contribution to weight gain is not important. Only 
      leptin was relevant as a predictor of weight gain at the 3-month endpoint.
FAU - Trevino-Garza, Consuelo
AU  - Trevino-Garza C
FAU - Estrada-Zuniga, Cynthia M
AU  - Estrada-Zuniga CM
FAU - Mancillas-Adame, Leonardo
AU  - Mancillas-Adame L
FAU - Villarreal-Martinez, Laura
AU  - Villarreal-Martinez L
FAU - Villarreal-Perez, Jesus Z
AU  - Villarreal-Perez JZ
FAU - Rodriguez-Balderrama, Isaias
AU  - Rodriguez-Balderrama I
FAU - Montes-Tapia, Fernando F
AU  - Montes-Tapia FF
FAU - de la O Cavazos, Manuel E
AU  - de la O Cavazos ME
AD  - Cavazos MD, University Autonomous of Nuevo Leon, 'Dr. Jose E. Gonzalez' 
      University Hospital, Department of Pediatrics, Monterrey/Nuevo Leon, Mexico 
      Phone: +52 (81) 83469959 E-mail: delaocavazos@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20160418
PL  - Turkey
TA  - J Clin Res Pediatr Endocrinol
JT  - Journal of clinical research in pediatric endocrinology
JID - 101519456
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Resistin)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adipokines/*blood
MH  - Adiponectin/blood
MH  - Adipose Tissue/metabolism
MH  - Birth Weight
MH  - Chemokine CCL2/blood
MH  - Fetal Blood/*metabolism
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoassay/methods
MH  - Infant
MH  - Infant, Newborn
MH  - Interleukin-6/blood
MH  - Leptin/*blood
MH  - Multivariate Analysis
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Predictive Value of Tests
MH  - Resistin/blood
MH  - Tumor Necrosis Factor-alpha/blood
MH  - *Weight Gain
PMC - PMC5096496
EDAT- 2016/04/19 06:00
MHDA- 2017/04/19 06:00
PMCR- 2016/09/01
CRDT- 2016/04/19 06:00
PHST- 2016/04/19 06:00 [entrez]
PHST- 2016/04/19 06:00 [pubmed]
PHST- 2017/04/19 06:00 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - 1784 [pii]
AID - 10.4274/jcrpe.2693 [doi]
PST - ppublish
SO  - J Clin Res Pediatr Endocrinol. 2016 Sep 1;8(3):321-4. doi: 10.4274/jcrpe.2693. 
      Epub 2016 Apr 18.