PMID- 27087808
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160418
LR  - 20201001
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2016
DP  - 2016
TI  - Trimester- and Assay-Specific Thyroid Reference Intervals for Pregnant Women in 
      China.
PG  - 3754213
LID - 10.1155/2016/3754213 [doi]
LID - 3754213
AB  - Objective. The guidelines of the American Thyroid Association (ATA) recommend an 
      upper limit reference interval (RI) of thyroid stimulating hormone (TSH) of 
      2.5 mIU/L in the first trimester of pregnancy and 3.0 mIU/L in subsequent 
      trimesters, but some reported ranges in China are significantly higher. Our study 
      aimed to establish trimester- and assay-specific RIs for thyroid hormones in 
      normal pregnant Chinese women. Methods. In this cross-sectional study, 2540 women 
      with normal pregnancies (first trimester, n = 398; second trimester, n = 797; 
      third trimester, n = 1345) and 237 healthy nonpregnant control subjects were 
      recruited. Serum TSH, free thyroxin (FT4), thyroid peroxidase antibody (TPOAb), 
      and thyroglobulin antibody (TgAb) levels were determined by automated 
      chemiluminescence with an Immulite 2000 system (Siemens, Erlangen, Germany). 
      After outliers were excluded, the 2.5-97.5th percentiles were used to define the 
      RIs. Results. The RIs of thyroid function in the first, second, and third 
      trimesters of pregnancy and in nonpregnant controls were 0.07-3.96, 0.27-4.53, 
      0.48-5.40, and 0.69-5.78 mIU/L for TSH and 9.16-18.12, 8.67-16.21, 7.80-13.90, 
      and 8.24-16.61 pmol/L for FT4, respectively. Conclusion. The trimester- and 
      assay-specific RIs of thyroid function during pregnancy differed between 
      trimesters, which suggests that it is advisable to detect and avoid 
      misclassification of thyroid dysfunction during pregnancy for women in Henan, 
      China.
FAU - Xing, Jinfang
AU  - Xing J
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
FAU - Yuan, Enwu
AU  - Yuan E
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
FAU - Li, Jing
AU  - Li J
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
FAU - Zhang, Yuchao
AU  - Zhang Y
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
FAU - Meng, Xiangying
AU  - Meng X
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
FAU - Zhang, Xia
AU  - Zhang X
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
FAU - Rong, Shouhua
AU  - Rong S
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
FAU - Lv, Zhongxing
AU  - Lv Z
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
FAU - Tian, Yuan
AU  - Tian Y
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
FAU - Jia, Liting
AU  - Jia L
AD  - Clinical Laboratory Department, The Third Affiliated Hospital of Zhengzhou 
      University, No. 7 Front Kangfu Street, Er'qi Distric, Zhengzhou 450052, China.
LA  - eng
PT  - Journal Article
DEP - 20160321
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC4819108
EDAT- 2016/04/19 06:00
MHDA- 2016/04/19 06:01
PMCR- 2016/03/21
CRDT- 2016/04/19 06:00
PHST- 2016/01/02 00:00 [received]
PHST- 2016/03/02 00:00 [revised]
PHST- 2016/03/03 00:00 [accepted]
PHST- 2016/04/19 06:00 [entrez]
PHST- 2016/04/19 06:00 [pubmed]
PHST- 2016/04/19 06:01 [medline]
PHST- 2016/03/21 00:00 [pmc-release]
AID - 10.1155/2016/3754213 [doi]
PST - ppublish
SO  - Int J Endocrinol. 2016;2016:3754213. doi: 10.1155/2016/3754213. Epub 2016 Mar 21.