PMID- 27087962
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160418
LR  - 20181113
IS  - 2050-6406 (Print)
IS  - 2050-6414 (Electronic)
IS  - 2050-6406 (Linking)
VI  - 4
IP  - 2
DP  - 2016 Apr
TI  - The burden of bowel preparations in patients undergoing elective colonoscopy.
PG  - 314-8
LID - 10.1177/2050640615594550 [doi]
AB  - BACKGROUND: An adequate bowel preparation is an important quality measure for 
      optimal colonoscopy. AIMS: The aim of this article is to study the burden of 
      bowel preparations by examining seven specific variables (hunger, taste, volume, 
      sleep, social, work, and adverse events (AEs)). METHODS: Ambulatory patients 
      undergoing elective colonoscopy completed a questionnaire regarding their 
      experience with the prescribed preparation. The seven study variables were graded 
      using a numerical scale of 0-10 (best to worst). A score >6 was considered to 
      indicate a significant impact and used as primary outcome. Patients were also 
      asked to grade in descending order what they perceived as the worst aspect of the 
      preparation. RESULTS: A total of 216 patients completed the survey. Preparations 
      consisted of split-dose sodium picosulfate (SPS) (n = 49), split-dose 4 l 
      PEG +/- menthol (n = 49), full-dose PEG (n = 68), and 2 l split-dose PEG + ascorbic 
      acid (n = 50). Except for work and AEs, all variables were considered to have a 
      negative impact by >20% of patients (range 20.4-34.2). SPS was superior to PEG 
      regimens in taste (4.1% vs. 35.9%) and volume (0% vs. 44.9%) (p < 0.05 for both) 
      but inferior for hunger (30.6% vs. 19.2%; p = 0.09). The addition of menthol to 
      PEG significantly improved taste (22.4% vs. 41.5%; p = 0.02). Sleep disturbances 
      were most common with SPS and least with split-dose PEG (30.6% vs. 17.4%; 
      p < 0.05). Overall, patients ranked volume, taste, and hunger as most burdensome. 
      CONCLUSIONS: The burden of bowel preparation is substantial. An informed 
      personalized choice of preparation may improve adherence, tolerability and colon 
      cleansing.
FAU - Sharara, Ala I
AU  - Sharara AI
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - El Reda, Zeinab D
AU  - El Reda ZD
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - Harb, Ali H
AU  - Harb AH
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - Abou Fadel, Carla G
AU  - Abou Fadel CG
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - Sarkis, Fayez S
AU  - Sarkis FS
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - Chalhoub, Jean M
AU  - Chalhoub JM
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
FAU - Abou Mrad, Rachel
AU  - Abou Mrad R
AD  - Division of Gastroenterology, Department of Internal Medicine, American 
      University of Beirut Medical Center, Beirut, Lebanon.
LA  - eng
PT  - Journal Article
DEP - 20150703
PL  - England
TA  - United European Gastroenterol J
JT  - United European gastroenterology journal
JID - 101606807
PMC - PMC4804361
OTO - NOTNLM
OT  - Colonoscopy
OT  - acceptability
OT  - adherence
OT  - bowel preparation
OT  - quality of life
OT  - tolerability
EDAT- 2016/04/19 06:00
MHDA- 2016/04/19 06:01
PMCR- 2016/04/01
CRDT- 2016/04/19 06:00
PHST- 2015/04/04 00:00 [received]
PHST- 2015/06/10 00:00 [accepted]
PHST- 2016/04/19 06:00 [entrez]
PHST- 2016/04/19 06:00 [pubmed]
PHST- 2016/04/19 06:01 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.1177_2050640615594550 [pii]
AID - 10.1177/2050640615594550 [doi]
PST - ppublish
SO  - United European Gastroenterol J. 2016 Apr;4(2):314-8. doi: 
      10.1177/2050640615594550. Epub 2015 Jul 3.