PMID- 27089512
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180529
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 32
IP  - 18
DP  - 2016 May 10
TI  - Photothermally Triggered Lipid Bilayer Phase Transition and Drug Release from 
      Gold Nanorod and Indocyanine Green Encapsulated Liposomes.
PG  - 4554-63
LID - 10.1021/acs.langmuir.6b00716 [doi]
AB  - In light-activated liposomal drug delivery systems (DDSs), the light sensitivity 
      can be obtained by a photothermal agent that converts light energy into heat. 
      Excess heat increases the drug permeability of the lipid bilayer, and drug is 
      released as a result. In this work, two near-IR responsive photothermal agents in 
      a model drug delivery system are studied: either gold nanorods (GNRs) 
      encapsulated inside the liposomes or indocyanine green (ICG) embedded into the 
      lipid bilayer. The liposome system is exposed to light, and the heating effect is 
      studied with fluorescent thermometers: laurdan and CdSe quantum dots (QDs). Both 
      photothermal agents are shown to convert light into heat in an extent to cause a 
      phase transition in the surrounding lipid bilayer. This phase transition is also 
      proven with laurdan generalized polarization (GP). In addition to the heating 
      results, we show that the model drug (calcein) is released from the liposomal 
      cavity with both photothermal agents when the light power is sufficient to cause 
      a phase transition in the lipid bilayer.
FAU - Viitala, Lauri
AU  - Viitala L
AD  - Department of Chemistry, Aalto University , P.O. Box 16100, FI-00076 Aalto, 
      Finland.
FAU - Pajari, Saija
AU  - Pajari S
AD  - Department of Chemistry, Aalto University , P.O. Box 16100, FI-00076 Aalto, 
      Finland.
FAU - Lajunen, Tatu
AU  - Lajunen T
AD  - Faculty of Pharmacy, University of Helsinki , P.O. Box 56, FI-00014 Helsinki, 
      Finland.
FAU - Kontturi, Leena-Stiina
AU  - Kontturi LS
AD  - Faculty of Pharmacy, University of Helsinki , P.O. Box 56, FI-00014 Helsinki, 
      Finland.
AD  - Department of Pharmaceutics, Utrecht University , Universiteitsweg 99, 3584 CG, 
      Utrecht, The Netherlands.
FAU - Laaksonen, Timo
AU  - Laaksonen T
AD  - Faculty of Pharmacy, University of Helsinki , P.O. Box 56, FI-00014 Helsinki, 
      Finland.
FAU - Kuosmanen, Paivi
AU  - Kuosmanen P
AD  - Department of Chemistry, Aalto University , P.O. Box 16100, FI-00076 Aalto, 
      Finland.
FAU - Viitala, Tapani
AU  - Viitala T
AD  - Faculty of Pharmacy, University of Helsinki , P.O. Box 56, FI-00014 Helsinki, 
      Finland.
FAU - Urtti, Arto
AU  - Urtti A
AD  - Faculty of Pharmacy, University of Helsinki , P.O. Box 56, FI-00014 Helsinki, 
      Finland.
AD  - School of Pharmacy, University of Eastern Finland , P.O. Box 1627, FI-70211 
      Kuopio, Finland.
FAU - Murtomaki, Lasse
AU  - Murtomaki L
AD  - Department of Chemistry, Aalto University , P.O. Box 16100, FI-00076 Aalto, 
      Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160426
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Capsules)
RN  - 0 (Lipid Bilayers)
RN  - 0 (Liposomes)
RN  - 7440-57-5 (Gold)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Capsules
MH  - *Drug Liberation
MH  - Gold/*chemistry
MH  - Indocyanine Green/*chemistry
MH  - *Light
MH  - Lipid Bilayers/*chemistry
MH  - Liposomes
MH  - Nanotubes/*chemistry
MH  - *Phase Transition
MH  - Safety
MH  - *Temperature
EDAT- 2016/04/19 06:00
MHDA- 2018/05/31 06:00
CRDT- 2016/04/19 06:00
PHST- 2016/04/19 06:00 [entrez]
PHST- 2016/04/19 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
AID - 10.1021/acs.langmuir.6b00716 [doi]
PST - ppublish
SO  - Langmuir. 2016 May 10;32(18):4554-63. doi: 10.1021/acs.langmuir.6b00716. Epub 
      2016 Apr 26.