PMID- 27090038
OWN - NLM
STAT- MEDLINE
DCOM- 20160602
LR  - 20170511
IS  - 0001-5385 (Print)
IS  - 0001-5385 (Linking)
VI  - 71
IP  - 2
DP  - 2016 Apr
TI  - Decrease of circulating myeloid dendritic cells in patients with chronic heart 
      failure.
PG  - 165-72
LID - 10.2143/AC.71.2.3141846 [doi]
AB  - AIMS: Immunity and inflammation processes are known to be of central importance 
      in chronic heart failure (CHF). Dendritic cells (DCs) are key players in adaptive 
      immunity, yet their role in CHF is still unknown. The aim of this study was to 
      investigate the circulating DCs in patients with compensated CHF. METHODS: 
      Circulating myeloid (m) and plasmacytoid (p) DCs, as well as inflammatory 
      cytokines interleukine (IL) 6 and IL10 were flow cytometrically analysed in 
      peripheral blood of clinically compensated CHF patients with previously diagnosed 
      dilated cardiomyopathy (DCM, n = 69), ischaemic cardiomyopathy (ICM, n = 49), as 
      well as in unaffected controls (n = 51). Correlation analysis was performed 
      between circulating DCs, cytokines and parameters of heart failure severity, such 
      as NYHA class, the marker brain natriuretic peptide (BNP) and echocardiographic 
      parameters of left ventricular function and dilation. RESULTS: Circulating mDCs 
      were significantly decreased in all CHF patients, although more pronounced in DCM 
      (0.14%, P < 0.001) than in ICM (0.18%, P = 0.043) compared to controls (0.2%). In 
      contrast, no statistical changes were observed for pDCs. Circulating mDCs 
      correlated with left ventricular ejection fraction (LVEF) and inversely with LV 
      end-diastolic diameter (LVEDd) in all CHF patients. For DCM patients, an inverse 
      correlation of mDCs with BNP was additionally observed. Circulating mDCs 
      correlated inversely with IL6 and IL10 in all CHF patients. With the exception of 
      IL-6 and NYHA class of DCM patients, cytokines did not significantly correlate 
      with heart failure parameters. CONCLUSIONS: Blood mDCs are decreased in CHF 
      patients. The reduction correlates with the severity of their HF.
FAU - Pistulli, Rudin
AU  - Pistulli R
FAU - Hammer, Nadin
AU  - Hammer N
FAU - Rohm, Ilonka
AU  - Rohm I
FAU - Kretzschmar, Daniel
AU  - Kretzschmar D
FAU - Jung, Christian
AU  - Jung C
FAU - Figulla, Hans-Reiner
AU  - Figulla HR
FAU - Yilmaz, Atilla
AU  - Yilmaz A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
RN  - 0 (Cytokines)
SB  - IM
MH  - Adaptive Immunity
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/*complications
MH  - Chronic Disease
MH  - Cytokines/*blood
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - *Heart Failure/etiology/immunology/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*complications
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - Ventricular Function, Left/immunology
OTO - NOTNLM
OT  - Chronic heart failure
OT  - cytokine
OT  - dendritic cell
OT  - dilated cardiomyopathy
OT  - ischaemic cardiomyopathy
EDAT- 2016/04/20 06:00
MHDA- 2016/06/03 06:00
CRDT- 2016/04/20 06:00
PHST- 2016/04/20 06:00 [entrez]
PHST- 2016/04/20 06:00 [pubmed]
PHST- 2016/06/03 06:00 [medline]
AID - 10.2143/AC.71.2.3141846 [doi]
PST - ppublish
SO  - Acta Cardiol. 2016 Apr;71(2):165-72. doi: 10.2143/AC.71.2.3141846.