PMID- 27090108
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20170309
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 92
DP  - 2016 Jun
TI  - Vitamin C intervention may lower the levels of persistent organic pollutants in 
      blood of healthy women - A pilot study.
PG  - 197-204
LID - S0278-6915(16)30112-0 [pii]
LID - 10.1016/j.fct.2016.04.006 [doi]
AB  - Emerging evidence suggests that exposure to endocrine-disrupting chemicals 
      including persistent organic pollutants (POPs) such as organochlorine pesticides 
      (OCPs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers 
      (PBDEs) has a long term impact on human health. The goal of this pilot study was 
      to test whether antioxidant intervention by vitamin C supplementation may be a 
      remedial approach to decrease body burden of POPs in humans. Using solid phase 
      extraction coupled with a triple quadrupole mass spectrometer and a gas 
      chromatography high resolution mass spectrometry, we measured 18 PCBs, 7 OCPs, 
      and 5 PBDEs in the blood of 15 healthy California women (8 were obese/overweight 
      and 7 had normal weight) before and after 2 months of vitamin C supplementation 
      (1000 mg/day). We observed higher PBDE levels than PCBs and OCPs, but only PCB 
      and OCP levels were strongly and positively correlated with participant's BMI and 
      age. We also found statistically significant decreases in 6 PCBs (PCB-74, 
      PCB-118, PCB-138, PCB-153, PCB-180, and PCB-187), and 2 OCPs (4,4'-DDE, and 
      4,4'-DDT), but not PBDEs after vitamin C supplementation. Pending confirmation of 
      this pilot finding in a larger study of both sexes, vitamin C intervention may 
      have important public health implications in protecting health by reducing body 
      burdens of POPs.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Guo, Weihong
AU  - Guo W
AD  - Environmental Chemistry Laboratory, California Department of Toxic Substances 
      Control, 700 Heinz Ave, S. 100, Berkeley, CA 94710, USA. Electronic address: 
      weihong.guo@dtsc.ca.gov.
FAU - Huen, Karen
AU  - Huen K
AD  - School of Public Health, 50 University Hall, University of California, Berkeley, 
      CA 94720, USA.
FAU - Park, June-Soo
AU  - Park JS
AD  - Environmental Chemistry Laboratory, California Department of Toxic Substances 
      Control, 700 Heinz Ave, S. 100, Berkeley, CA 94710, USA.
FAU - Petreas, Myrto
AU  - Petreas M
AD  - Environmental Chemistry Laboratory, California Department of Toxic Substances 
      Control, 700 Heinz Ave, S. 100, Berkeley, CA 94710, USA.
FAU - Crispo Smith, Sabrina
AU  - Crispo Smith S
AD  - Environmental Chemistry Laboratory, California Department of Toxic Substances 
      Control, 700 Heinz Ave, S. 100, Berkeley, CA 94710, USA; Sequoia Foundation, 2166 
      Avenida De La Playa, La Jolla, CA 92037, USA.
FAU - Block, Gladys
AU  - Block G
AD  - School of Public Health, 50 University Hall, University of California, Berkeley, 
      CA 94720, USA.
FAU - Holland, Nina
AU  - Holland N
AD  - School of Public Health, 50 University Hall, University of California, Berkeley, 
      CA 94720, USA.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160423
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Antioxidants)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Antioxidants/*administration & dosage
MH  - Ascorbic Acid/*administration & dosage
MH  - California
MH  - *Dietary Supplements
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Organic Chemicals/*blood
MH  - Pesticides/blood
MH  - Pilot Projects
OTO - NOTNLM
OT  - Intervention
OT  - OCPs
OT  - PBDEs
OT  - PCBs
OT  - Persistent organic pollutants
OT  - Vitamin C
EDAT- 2016/04/20 06:00
MHDA- 2017/03/10 06:00
CRDT- 2016/04/20 06:00
PHST- 2015/12/18 00:00 [received]
PHST- 2016/04/06 00:00 [revised]
PHST- 2016/04/09 00:00 [accepted]
PHST- 2016/04/20 06:00 [entrez]
PHST- 2016/04/20 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
AID - S0278-6915(16)30112-0 [pii]
AID - 10.1016/j.fct.2016.04.006 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2016 Jun;92:197-204. doi: 10.1016/j.fct.2016.04.006. Epub 2016 
      Apr 23.