PMID- 27090416
OWN - NLM
STAT- MEDLINE
DCOM- 20161012
LR  - 20220311
IS  - 1129-2377 (Electronic)
IS  - 1129-2369 (Print)
IS  - 1129-2369 (Linking)
VI  - 17
DP  - 2016
TI  - Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the 
      urotensin-2 gene are associated with migraines.
PG  - 36
LID - 10.1186/s10194-016-0623-z [doi]
LID - 36
AB  - BACKGROUND: Urotensin-II (U-II) is a peptide recognized by its potent 
      vasoconstrictor activity in many vascular events, however the role of 
      urotensin-II in migraine has not been considered yet. The molecular mechanisms 
      and genetics of migraine have not been fully clarified yet, but it is well-known 
      that vascular changes considerably contribute in pathophysiology of migraine and 
      also its complications. The aim of this study was to analyze the plasma U-II 
      levels along with genotype distributions and allele frequencies for UTS2 Thr21Met 
      and Ser89Asn polymorphisms among the patients with migraine without aura (MWoA). 
      METHODS: One hundred eighty-six patients with MWoA and 171 healthy individuals 
      were included in this study. Plasma U-II levels were measured in attack free 
      period. The genotype and allele frequencies for the Thr21Met (T21M) and Ser89Asn 
      (S89N) polymorphisms in the UTS2 gene were analyzed. RESULTS: Plasma U-II levels 
      were significantly higher in MWoA patients (p = 0.002). We detected a significant 
      association between the T21M polymorphism in the UTS2 gene and migraine (53.8 % 
      in patients, 40.4 % in controls, p = 0.035), but not with S89N polymorphism 
      (p = 0.620). A significant relationship was found between U-II levels and MIDAS 
      score (beta = 0.508, p = 0.001). CONCLUSION: Our study suggests that U-II may play a 
      role in migraine pathogenesis; also Thr21Met polymorphism was associated with the 
      risk of migraine disease. Further studies are needed for considering the role of 
      U-II in migraine pathophysiology and for deciding if UTS2 gene may be a novel 
      candidate gene in migraine cases.
FAU - Geyik, Sirma
AU  - Geyik S
AD  - Department of Neurology, Faculty of Medicine, University of Gaziantep, Gaziantep, 
      Turkey. drsirmageyik@hotmail.com.
FAU - Ergun, Sercan
AU  - Ergun S
AD  - Ulubey Vocational Higher School, Ordu University, Ordu, Turkey.
FAU - Kuzudisli, Samiye
AU  - Kuzudisli S
AD  - Department of Neurology, Emine-Bahaeddin Nakiboglu Medical Faculty, Zirve 
      University, Gaziantep, Turkey.
FAU - Sensoy, Figen
AU  - Sensoy F
AD  - Neurology Clinics, Medical Park Hospital, Gaziantep, Turkey.
FAU - Temiz, Ebru
AU  - Temiz E
AD  - Department of Medical Biology, Faculty of Medicine, University of Gaziantep, 
      Gaziantep, Turkey.
FAU - Altunisik, Erman
AU  - Altunisik E
AD  - Division Of Neurology, Turkish Ministry Of Health Siirt State Hospital, Siirt, 
      Turkey.
FAU - Korkmaz, Murat
AU  - Korkmaz M
AD  - Department of Medical Biology, Faculty of Medicine, University of Gaziantep, 
      Gaziantep, Turkey.
FAU - Dagli, Hasan
AU  - Dagli H
AD  - Department of Medical Biology, Faculty of Medicine, University of Gaziantep, 
      Gaziantep, Turkey.
FAU - Kul, Seval
AU  - Kul S
AD  - Department of Biostatistics, Faculty of Medicine, University of Gaziantep, 
      Gaziantep, Turkey.
FAU - Akcali, Aylin
AU  - Akcali A
AD  - Department of Neurology, Faculty of Medicine, University of Gaziantep, Gaziantep, 
      Turkey.
FAU - Neyal, Ayse Munife
AU  - Neyal AM
AD  - Department of Neurology, Faculty of Medicine, University of Gaziantep, Gaziantep, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160418
PL  - England
TA  - J Headache Pain
JT  - The journal of headache and pain
JID - 100940562
RN  - 0 (Urotensins)
RN  - 9047-55-6 (urotensin II)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Migraine Disorders/*blood/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Urotensins/*blood/*genetics
MH  - Young Adult
PMC - PMC4835397
OTO - NOTNLM
OT  - ELISA
OT  - Migraine without aura
OT  - Ser89Asn
OT  - Thr21Met
OT  - UTS2 gene polymorphisms
OT  - Urotensin-2
EDAT- 2016/04/20 06:00
MHDA- 2016/10/13 06:00
PMCR- 2016/04/18
CRDT- 2016/04/20 06:00
PHST- 2016/03/03 00:00 [received]
PHST- 2016/04/07 00:00 [accepted]
PHST- 2016/04/20 06:00 [entrez]
PHST- 2016/04/20 06:00 [pubmed]
PHST- 2016/10/13 06:00 [medline]
PHST- 2016/04/18 00:00 [pmc-release]
AID - 10.1186/s10194-016-0623-z [pii]
AID - 623 [pii]
AID - 10.1186/s10194-016-0623-z [doi]
PST - ppublish
SO  - J Headache Pain. 2016;17:36. doi: 10.1186/s10194-016-0623-z. Epub 2016 Apr 18.