PMID- 27090485
OWN - NLM
STAT- MEDLINE
DCOM- 20170928
LR  - 20171210
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 80
DP  - 2016 Jul
TI  - Voluntary muscle activation improves with power training and is associated with 
      changes in gait speed in mobility-limited older adults - A randomized controlled 
      trial.
PG  - 51-6
LID - S0531-5565(16)30086-9 [pii]
LID - 10.1016/j.exger.2016.03.018 [doi]
AB  - Incomplete voluntary muscle activation may contribute to impaired muscle 
      mechanical function and physical function in older adults. Exercise interventions 
      have been shown to increase voluntary muscle activation, although the evidence is 
      sparse for mobility-limited older adults, particularly in association with 
      physical function. This study examined the effects of 12weeks of power training 
      on outcomes of voluntary muscle activation and gait speed in mobility-limited 
      older adults from the Healthy Ageing Network of Competence (HANC) study. We 
      included 37 older men and women with a usual gait speed of <0.9m/s in the 
      per-protocol analysis: n=16 in the training group (TG: 12weeks of progressive 
      high-load power training, 2 sessions per week; age: 82.3+/-1.3years, 56% women) and 
      n=21 in the control group (CG: no interventions; age: 81.6+/-1.1years, 67% women). 
      Knee extensor muscle thickness (ultrasonography), strength (isokinetic 
      dynamometry), voluntary activation (interpolated twitch technique), and gait 
      speed (2-min maximal walking test) were assessed at baseline and 
      post-intervention. At baseline, TG and CG were comparable for all measures. 
      Post-intervention, significant between-group changes (TG vs. CG; p<0.05) were 
      observed for voluntary muscle activation (+6.2%), muscle strength (+13.4Nm), and 
      gait speed (+0.12m/s), whereas the between-group change in muscle thickness was 
      non-significant (+0.08cm). Improvements in voluntary muscle activation were 
      associated with improvements in gait speed in TG (r=0.67, p<0.05). Importantly, 
      voluntary muscle activation is improved in mobility-limited older adults 
      following 12-weeks of progressive power training, and is associated with improved 
      maximal gait speed. Incomplete voluntary muscle activation should be considered 
      one of the key mechanisms influencing muscle mechanical function and gait speed 
      in older adults.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Hvid, Lars G
AU  - Hvid LG
AD  - Department of Sports Science and Clinical Biomechanics, SDU Muscle Research 
      Cluster (SMRC), University of Southern Denmark, Odense, Denmark. Electronic 
      address: lhvid@health.sdu.dk.
FAU - Strotmeyer, Elsa S
AU  - Strotmeyer ES
AD  - Center for Aging and Population Health, Department of Epidemiology, Graduate 
      School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Skjodt, Mathias
AU  - Skjodt M
AD  - Department of Sports Science and Clinical Biomechanics, SDU Muscle Research 
      Cluster (SMRC), University of Southern Denmark, Odense, Denmark.
FAU - Magnussen, Line V
AU  - Magnussen LV
AD  - Department of Endocrinology, Odense University Hospital, Odense, Denmark.
FAU - Andersen, Marianne
AU  - Andersen M
AD  - Department of Endocrinology, Odense University Hospital, Odense, Denmark.
FAU - Caserotti, Paolo
AU  - Caserotti P
AD  - Department of Sports Science and Clinical Biomechanics, SDU Muscle Research 
      Cluster (SMRC), University of Southern Denmark, Odense, Denmark; National 
      Institutes of Health, National Institute on Aging, Laboratory of Epidemiology and 
      Population Sciences (LPES), Bethesda, MD, USA.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20160414
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Denmark
MH  - Female
MH  - Humans
MH  - Male
MH  - *Mobility Limitation
MH  - Muscle Strength/*physiology
MH  - Muscle, Skeletal/*physiology
MH  - Resistance Training
MH  - *Walking Speed
OTO - NOTNLM
OT  - Aging
OT  - Gait speed
OT  - Mobility
OT  - Muscle function
OT  - Power training
OT  - Voluntary muscle activation
EDAT- 2016/04/20 06:00
MHDA- 2017/09/29 06:00
CRDT- 2016/04/20 06:00
PHST- 2015/11/20 00:00 [received]
PHST- 2016/02/22 00:00 [revised]
PHST- 2016/03/29 00:00 [accepted]
PHST- 2016/04/20 06:00 [entrez]
PHST- 2016/04/20 06:00 [pubmed]
PHST- 2017/09/29 06:00 [medline]
AID - S0531-5565(16)30086-9 [pii]
AID - 10.1016/j.exger.2016.03.018 [doi]
PST - ppublish
SO  - Exp Gerontol. 2016 Jul;80:51-6. doi: 10.1016/j.exger.2016.03.018. Epub 2016 Apr 
      14.