PMID- 27091718
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20221207
IS  - 1488-2434 (Electronic)
IS  - 1180-4882 (Print)
IS  - 1180-4882 (Linking)
VI  - 41
IP  - 6
DP  - 2016 Oct
TI  - Common susceptibility variants are shared between schizophrenia and psoriasis in 
      the Han Chinese population.
PG  - 413-421
AB  - BACKGROUND: Previous studies have shown that individuals with schizophrenia have 
      a greater risk for psoriasis than a typical person. This suggests that there 
      might be a shared genetic etiology between the 2 conditions. We aimed to 
      characterize the potential shared genetic susceptibility between schizophrenia 
      and psoriasis using genome-wide marker genotype data. METHODS: We obtained 
      genetic data on individuals with psoriasis, schizophrenia and control 
      individuals. We applied a marker-based coheritability estimation procedure, 
      polygenic score analysis, a gene set enrichment test and a least absolute 
      shrinkage and selection operator regression model to estimate the potential 
      shared genetic etiology between the 2 diseases. We validated the results in 
      independent schizophrenia and psoriasis cohorts from Singapore. RESULTS: We 
      included 1139 individuals with psoriasis, 744 with schizophrenia and 1678 
      controls in our analysis, and we validated the results in independent cohorts, 
      including 441 individuals with psoriasis (and 2420 controls) and 1630 with 
      schizophrenia (and 1860 controls). We estimated that a large fraction of 
      schizophrenia and psoriasis risk could be attributed to common variants 
      (h(2)(SNP) = 29% +/- 5.0%, p = 2.00 x 10(-8)), with a coheritability estimate 
      between the traits of 21%. We identified 5 variants within the human leukocyte 
      antigen (HLA) gene region, which were most likely to be associated with both 
      diseases and collectively conferred a significant risk effect (odds ratio of 
      highest risk quartile = 6.03, p < 2.00 x 10(-16)). We discovered that variants 
      contributing most to the shared heritable component between psoriasis and 
      schizophrenia were enriched in antigen processing and cell endoplasmic reticulum. 
      LIMITATIONS: Our sample size was relatively small. The findings of 5 HLA gene 
      variants were complicated by the complex structure in the HLA region. CONCLUSION: 
      We found evidence for a shared genetic etiology between schizophrenia and 
      psoriasis. The mechanism for this shared genetic basis likely involves immune and 
      calcium signalling pathways.
FAU - Yin, Xianyong
AU  - Yin X
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Wineinger, Nathan E
AU  - Wineinger NE
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Wang, Kai
AU  - Wang K
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Yue, Weihua
AU  - Yue W
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Norgren, Nina
AU  - Norgren N
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Wang, Ling
AU  - Wang L
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Yao, Weiyi
AU  - Yao W
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Jiang, Xiaoyun
AU  - Jiang X
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Wu, Bo
AU  - Wu B
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Cui, Yong
AU  - Cui Y
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Shen, Changbing
AU  - Shen C
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Cheng, Hui
AU  - Cheng H
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Zhou, Fusheng
AU  - Zhou F
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Chen, Gang
AU  - Chen G
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Zuo, Xianbo
AU  - Zuo X
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Zheng, Xiaodong
AU  - Zheng X
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Fan, Xing
AU  - Fan X
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Wang, Hongyan
AU  - Wang H
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Wang, Lifang
AU  - Wang L
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Lee, Jimmy
AU  - Lee J
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Lam, Max
AU  - Lam M
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Tai, E Shyong
AU  - Tai ES
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Zhang, Zheng
AU  - Zhang Z
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Huang, Qiong
AU  - Huang Q
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Sun, Liangdan
AU  - Sun L
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Xu, Jinhua
AU  - Xu J
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Yang, Sen
AU  - Yang S
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Wilhelmsen, Kirk C
AU  - Wilhelmsen KC
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Liu, Jianjun
AU  - Liu J
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Schork, Nicholas J
AU  - Schork NJ
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
FAU - Zhang, Xuejun
AU  - Zhang X
AD  - From the Institute of Dermatology, Department of Dermatology of The First 
      Affiliated Hospital. Key lab of Dermatology Ministry of Education, Anhui Medical 
      University, Hefei, China (Yin, Jiang, Wu, Cui, Shen, Cheng, Zhou, Chen, Zuo, 
      Zhend, Fan, Wang, Sun, Yang, Zhang); the Institute of Dermatology, Huashan 
      Hospital, Fudan University, Shanghai, China (Yin, Zhang, Huang, Xu, Zhang); the 
      The Scripps Translational Science Institute, La Jolla, California, USA (Yin, 
      Wineinger, Schork); the Department of Molecular and Experimental Medicine, The 
      Scripps Research Institute, La Jolla, USA (Yin, Schork); Human Biology, J. Craig 
      Venter Institute, La Jolla, California, USA (Yin, Schork); the Department of 
      Genetics, and Renaissance Computing Institute, University of North Carolina at 
      Chapel Hill, Chapel Hill, USA (Yin); the Scripps Health, La Jolla, California, 
      USA (Wineinger); the Department of Neurology, the First Affiliated Hospital of 
      Anhui Medical University, Hefei, China (Wang); the Peking University Sixth 
      Hospital, Peking University Institute of Mental Health; Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Beijing, China (Yue, Wang); the 
      Peking University Sixth Hospital, Peking University Institute of Mental Health; 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 
      China (Yue, Wang); the Human Genetics, Genome Institute of Singapore, Singapore 
      (Norgren, Wang, Liu); the Institute of Mental Health, Singapore (Norgren, Wang, 
      Liu); the Institute of Mental Health, Singapore (Lee); the Saw Swee Hock School 
      of Public Health, National University of Singapore, Singapore 138672, Singapore 
      (Tai, Liu).
LA  - eng
GR  - R01 MH100351/MH/NIMH NIH HHS/United States
GR  - R01 DA030976/DA/NIDA NIH HHS/United States
GR  - UL1 TR001114/TR/NCATS NIH HHS/United States
GR  - U19 AG023122/AG/NIA NIH HHS/United States
GR  - R01 AG035020/AG/NIA NIH HHS/United States
GR  - R01 MH094483/MH/NIMH NIH HHS/United States
GR  - R21 AG045789/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - Canada
TA  - J Psychiatry Neurosci
JT  - Journal of psychiatry & neuroscience : JPN
JID - 9107859
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - China/ethnology
MH  - Cohort Studies
MH  - *Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Genome-Wide Association Study
MH  - Genotyping Techniques
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Middle Aged
MH  - Multifactorial Inheritance
MH  - Psoriasis/*genetics
MH  - Regression Analysis
MH  - Schizophrenia/*genetics
MH  - Singapore
MH  - Young Adult
PMC - PMC5082512
EDAT- 2016/10/22 06:00
MHDA- 2018/01/05 06:00
PMCR- 2016/11/01
CRDT- 2016/04/20 06:00
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
PHST- 2016/04/20 06:00 [entrez]
PHST- 2016/11/01 00:00 [pmc-release]
AID - 10.1503/jpn.150210 [pii]
AID - jpn-41-413 [pii]
AID - 10.1503/jpn.150210 [doi]
PST - ppublish
SO  - J Psychiatry Neurosci. 2016 Oct;41(6):413-421. doi: 10.1503/jpn.150210.