PMID- 27091860
OWN - NLM
STAT- MEDLINE
DCOM- 20170410
LR  - 20181113
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 44
IP  - 3
DP  - 2016 Jun
TI  - An investigation into potential gender-specific differences in myocardial 
      triglyceride content assessed by 1H-Magnetic Resonance Spectroscopy at 3Tesla.
PG  - 585-91
LID - 10.1177/0300060515603884 [doi]
AB  - OBJECTIVE: Over the past decade, myocardial triglyceride content has become an 
      accepted biomarker for chronic metabolic and cardiac disease. The purpose of this 
      study was to use proton (hydrogen 1)-magnetic resonance spectroscopy ((1)H-MRS) 
      at 3Tesla (3 T) field strength to assess potential gender-related differences in 
      myocardial triglyceride content in healthy individuals. METHODS: Cardiac MR 
      imaging was performed to enable accurate voxel placement and obtain functional 
      and morphological information. Double triggered (i.e., ECG and respiratory motion 
      gating) (1)H-MRS was used to quantify myocardial triglyceride levels for each 
      gender. Two-sample t-test and Mann-Whitney U-test were used for statistical 
      analyses. RESULTS: In total, 40 healthy volunteers (22 male, 18 female; aged >18 
      years and age matched) were included in the study. Median myocardial triglyceride 
      content was 0.28% (interquartile range [IQR] 0.17-0.42%) in male and 0.24% (IQR 
      0.14-0.45%) in female participants, and no statistically significant difference 
      was observed between the genders. Furthermore, no gender-specific difference in 
      ejection fraction was observed, although on average, male participants presented 
      with a higher mean +/- SD left ventricular mass (136.3 +/- 25.2 g) than female 
      participants (103.9 +/- 16.1 g). CONCLUSIONS: The study showed that (1)H-MRS is a 
      capable, noninvasive tool for acquisition of myocardial triglyceride metabolites. 
      Myocardial triglyceride concentration was shown to be unrelated to gender in this 
      group of healthy volunteers.
CI  - (c) The Author(s) 2016.
FAU - Petritsch, Bernhard
AU  - Petritsch B
AD  - Department of Diagnostic and Interventional Radiology, University Hospital of 
      Wurzburg, Wurzburg, Germany Petritsch_B@ukw.de.
FAU - Kostler, Herbert
AU  - Kostler H
AD  - Department of Diagnostic and Interventional Radiology, University Hospital of 
      Wurzburg, Wurzburg, Germany.
FAU - Gassenmaier, Tobias
AU  - Gassenmaier T
AD  - Department of Diagnostic and Interventional Radiology, University Hospital of 
      Wurzburg, Wurzburg, Germany.
FAU - Kunz, Andreas S
AU  - Kunz AS
AD  - Department of Diagnostic and Interventional Radiology, University Hospital of 
      Wurzburg, Wurzburg, Germany.
FAU - Bley, Thorsten A
AU  - Bley TA
AD  - Department of Diagnostic and Interventional Radiology, University Hospital of 
      Wurzburg, Wurzburg, Germany.
FAU - Horn, Michael
AU  - Horn M
AD  - Department of Diagnostic and Interventional Radiology, University Hospital of 
      Wurzburg, Wurzburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160418
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Protons)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Myocardium/*metabolism
MH  - *Protons
MH  - *Sex Characteristics
MH  - Triglycerides/*metabolism
PMC - PMC5536690
OTO - NOTNLM
OT  - 1H-Magnetic resonance spectroscopy (1H-MRS)
OT  - Cardiac
OT  - gender
OT  - magnetic resonance imaging
OT  - metabolism
OT  - myocardium
OT  - triglycerides
EDAT- 2016/04/20 06:00
MHDA- 2017/04/11 06:00
PMCR- 2016/06/01
CRDT- 2016/04/20 06:00
PHST- 2015/07/15 00:00 [received]
PHST- 2015/08/10 00:00 [accepted]
PHST- 2016/04/20 06:00 [entrez]
PHST- 2016/04/20 06:00 [pubmed]
PHST- 2017/04/11 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - 0300060515603884 [pii]
AID - 10.1177_0300060515603884 [pii]
AID - 10.1177/0300060515603884 [doi]
PST - ppublish
SO  - J Int Med Res. 2016 Jun;44(3):585-91. doi: 10.1177/0300060515603884. Epub 2016 
      Apr 18.