PMID- 27092274
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160419
LR  - 20220408
IS  - 2090-1984 (Print)
IS  - 2090-1992 (Electronic)
IS  - 2090-1992 (Linking)
VI  - 2016
DP  - 2016
TI  - Amtolmetin: A Reappraisal of NSAID with Gastroprotection.
PG  - 7103705
LID - 10.1155/2016/7103705 [doi]
LID - 7103705
AB  - Aim. To assess the gastrosparing effect of amtolmetin guacyl (AMG) against other 
      nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteo-/rheumatoid 
      arthritis. Methods. A literature search was done in the electronic databases 
      (PubMed, Google Scholar, Embase, and Scopus) with key words "amtolmetin guacyl", 
      "amtolmetin", and "arthritis"; filters were applied to obtain publications 
      between 01-Jan-1985 and 01-Oct-2015, which were "clinical trials" in 
      osteo-/rheumatoid arthritis patients and in "English language." Studies were 
      assessed using the Jadad criteria and trials with score >/= 3 were included in the 
      analysis to compare the safety and efficacy of AMG against other NSAIDs. Results. 
      Search yielded 19 publications of which 3 were included for analysis. Baseline 
      characteristics of patients were comparable between the AMG group and other 
      NSAIDs (diclofenac, celecoxib, and piroxicam) groups in all trials. Efficacy of 
      AMG was similar to the other NSAIDs compared in the trials. The number of adverse 
      events (AEs) reported was similar between both the groups; however, severe AEs 
      reported were significantly lower in the AMG group. Of note was the significant 
      lower number of duodenal ulcers after treatment in the AMG group. Conclusions. 
      AMG has efficacy similar to other NSAIDs and a safer gastrointestinal AE profile 
      when compared to the other NSAIDs.
FAU - Garg, Amit
AU  - Garg A
AD  - Global Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad 500034, India.
FAU - Shoeb, Ahsan
AU  - Shoeb A
AD  - Global Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad 500034, India.
FAU - Moodahadu, Latha Subramanya
AU  - Moodahadu LS
AD  - Global Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad 500034, India.
FAU - Sharma, Akhilesh
AU  - Sharma A
AD  - Global Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad 500034, India.
FAU - Gandhi, Arul
AU  - Gandhi A
AD  - Global Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad 500034, India.
FAU - Akku, Shyam
AU  - Akku S
AD  - Global Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad 500034, India.
LA  - eng
PT  - Journal Article
DEP - 20160322
PL  - United States
TA  - Arthritis
JT  - Arthritis
JID - 101566207
PMC - PMC4820613
EDAT- 2016/04/20 06:00
MHDA- 2016/04/20 06:01
PMCR- 2016/03/22
CRDT- 2016/04/20 06:00
PHST- 2015/11/16 00:00 [received]
PHST- 2016/03/06 00:00 [accepted]
PHST- 2016/04/20 06:00 [entrez]
PHST- 2016/04/20 06:00 [pubmed]
PHST- 2016/04/20 06:01 [medline]
PHST- 2016/03/22 00:00 [pmc-release]
AID - 10.1155/2016/7103705 [doi]
PST - ppublish
SO  - Arthritis. 2016;2016:7103705. doi: 10.1155/2016/7103705. Epub 2016 Mar 22.